Localization of chronic Chlamydia psittaci infection in the reproductive tract of sheep

The Journal of Infectious Diseases
J R Papp, P E Shewen

Abstract

Twelve sheep experimentally infected with Chlamydia psittaci during pregnancy either aborted or gave birth to weak, low-birth-weight lambs as a result of uteroplacental infection. Subsequently, these ewes excreted chlamydial antigen from their reproductive tracts during estrus. About 1 year after pregnancy failure, immunohistochemistry and polymerase chain reaction were used to examine sections of vagina, uterus, and oviduct for evidence of C. psittaci. Four noninfected control ewes were similarly examined. C. psittaci antigen or DNA was detected in vagina, uterus, and oviduct samples from chronically infected ewes. Endometrial cells in the basal stroma were the predominant site of infection. There was no obvious evidence of pathology associated with persistent infection, but increased numbers of plasma cells and intraepithelial lymphocytes were detected in the uterus. C. psittaci is a naturally occurring reproductive infection in sheep that persists following primary infection. Therefore, sheep provide an excellent model to study the host-parasite interactions that occur during natural infection and subsequent persistence.

Citations

Jun 10, 2005·Veterinary Research Communications·D J SamminM C McElroy
Nov 14, 1997·Journal of Reproductive Immunology·J R Papp, P E Shewen
Oct 3, 2000·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M BuschA Pospischil
May 16, 2007·Infection and Immunity·Jose Rey-LadinoRobert C Brunham
Mar 25, 2004·Infection and Immunity·Richard J HoganPeter Timms
Apr 1, 1997·Emerging Infectious Diseases·D M Jorgensen
Oct 24, 2008·Veterinary Microbiology·M R CaroJ Salinas
Oct 28, 2008·Veterinary Microbiology·Catherine E MilneDavid Longbottom
Oct 22, 2008·Veterinary Microbiology·Morag LivingstoneDavid Longbottom
Jul 2, 2003·Journal of Comparative Pathology·D Longbottom, L J Coulter
Jun 28, 2016·Theriogenology·M OseikriaF Fieni
Sep 10, 2016·Frontiers in Veterinary Science·Teresa García-SecoJulio Álvarez
Nov 7, 2008·Veterinary Microbiology·Konrad SachseDavid Longbottom

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