Localization of claudin-2 and claudin-3 in eutopic and ectopic endometrium is highly similar.

Archives of Gynecology and Obstetrics
Alena HoerscherLutz Konrad

Abstract

Claudins as the major components of tight junctions are important in maintaining cell-cell integrity and thus function as a barrier. Dysregulation of the claudins is often associated with loss of the epithelial phenotype, a process called epithelial-mesenchymal transition (EMT), which most often results in gain of migrative and invasive properties. However, the role of claudins in the endometrium or endometriosis has only rarely been examined. In this study, we investigated localization of claudin-2 and claudin-3 in the eutopic and ectopic endometrium with immunohistochemistry. A detailed quantification with HSCORE was performed for claudin-2 and claudin-3 in endometrium without endometriosis and in cases with endometriosis compared to the three endometriotic entities: peritoneal, ovarian, and deep-infiltrating endometriosis. We found a preferential localization of both claudins in the glandular and the luminal epithelial cells in the endometrium with and without endometriosis. Quantification of localization of both claudins showed no differences in eutopic endometrium of control cases compared to cases with endometriosis. Furthermore, both claudins are localized highly similar in the ectopic compared to the eutopic endometrium...Continue Reading

References

Aug 1, 1986·British Journal of Obstetrics and Gynaecology·D T Liu, A Hitchcock
Jul 19, 2005·Cancer Research·Erik W ThompsonDavid Tarin
Jun 27, 2006·Gynecologic Oncology·Gábor SobelCsilla Páska
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·X Y PanW Peng
Jul 24, 2008·Histochemistry and Cell Biology·Olivier De WeverGeert Berx
Aug 22, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·K D BallardJ T Wright
Oct 14, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Regine GaetjeManfred Kaufmann
Feb 10, 2009·Fertility and Sterility·Juliana MeolaLúcia Martelli
Apr 17, 2013·Physiological Reviews·Dorothee Günzel, Alan S L Yu
May 31, 2013·Human Reproduction Update·Vicky J YoungAndrew W Horne
Feb 12, 2017·Cell·Arthur W LambertRobert A Weinberg
Apr 19, 2017·Oncotarget·Yan-Meng Yang, Wan-Xi Yang
Apr 27, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·V H EisenbergV Shalev
Jun 11, 2017·Pflügers Archiv : European journal of physiology·Michael FrommSusanne M Krug
Jun 22, 2017·Annals of the New York Academy of Sciences·Rita RosenthalMichael Fromm
Oct 11, 2017·Reproductive Sciences·Lutz KonradHans-Rudolf Tinneberg
Nov 5, 2017·Fertility and Sterility·Stephan GordtsIvo Brosens
Feb 7, 2018·Reproductive Sciences·Lutz KonradHans-Rudolf Tinneberg
Jul 29, 2018·Trends in Molecular Medicine·Lindsey K SymonsChandrakant Tayade

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Citations

Jun 24, 2020·Journal of Clinical Medicine·Lutz KonradIvo Meinhold-Heerlein
Jun 18, 2020·Reproductive Sciences·Tadahi OkadaTakashi Kojima

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Software Mentioned

Adobe Photoshop
HSCORE
Leica application suite LAS
GraphPad Prism

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