Localization of decay accelerating factor in normal and diseased kidneys.

Kidney International
F G CosioN S Nahman

Abstract

Decay accelerating factor (DAF) is a cell membrane associated glycoprotein that inhibits C3 activation. In the present study we evaluated the presence of DAF in normal (N = 15) and diseased human kidneys (N = 76). Sections of frozen tissue were stained for DAF by immunoperoxidase, utilizing three mouse monoclonal anti-DAF anti-bodies. In normal kidneys, DAF was localized in the glomerular vascular pole, apparently in the juxtaglomerular apparatus (JGA). All other structures were negative for DAF. By contrast, in diseased kidneys, two types of abnormalities were detected. First, JGA-DAF was significantly decreased and this abnormality correlated with the pathologic diagnosis and with the presence of C3, IgM and/or fibrinogen in the glomeruli. Second, DAF was present in the glomerular mesangium (67%), renal interstitium (68%) and/or blood vessels (38%). The presence of DAF in the mesangium and interstitium of the kidney correlated with each other and correlated with C1q and C3 deposition in the glomerulus. Finally, vascular DAF was significantly more common in patients with electron dense deposits in the glomeruli. In summary, DAF is present in the normal kidney and is located exclusively in the glomerular vascular pole. In disea...Continue Reading

References

Jan 1, 1986·The Journal of Experimental Medicine·A S AschV Nussenzweig
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M E MedofV Nussenzweig
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M K PangburnH J Müller-Eberhard
Jan 1, 1983·Springer Seminars in Immunopathology·J S Sundsmo, D S Fair
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A Nicholson-WellerK F Austen

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Citations

Aug 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C PanC D West
Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T M BehrC E Angermann
Aug 14, 1999·Immunology·O B SpillerB P Morgan
Dec 9, 1998·Kidney International·P W Mathieson
Dec 9, 1998·Kidney International·M Nangaku
May 7, 1999·Kidney International·M Kitamura, L G Fine
Mar 22, 2001·Kidney International·W ZhouS H Sacks
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U K EwulonuM E Medof
Nov 3, 2010·Nephrology·Allison M Lesher, Wen-Chao Song
Apr 16, 2005·Clinical Microbiology Reviews·Alain L Servin
Jan 1, 1993·International Reviews of Immunology·G Schieren, G M Hänsch
Oct 29, 2013·Seminars in Nephrology·Abhijit NaikRichard J Quigg
Mar 6, 2007·Seminars in Nephrology·Lihua Bao, Richard J Quigg
May 30, 2007·Seminars in Nephrology·Tipu S Puri, Richard J Quigg
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Steven H Sacks, Wuding Zhou
Nov 18, 2003·Immunological Reviews·Attapong VongwiwatanaPhilip F Halloran
Nov 18, 2015·Seminars in Nephrology·Daniel J Birmingham, Lee A Hebert
Apr 6, 2004·Rheumatic Diseases Clinics of North America·Hector Molina
Jun 9, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Miguel González-MolinaDomingo Hernandez
Mar 24, 2005·Journal of Cellular and Molecular Medicine·Mihaela GherghiceanuE Mandache
Jan 4, 2001·Optometry and Vision Science : Official Publication of the American Academy of Optometry·L B SzczotkaM E Medof
Jan 30, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Lihua BaoRichard J Quigg
Oct 6, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Joshua M Thurman, Brandon Renner
Oct 28, 2018·Nature Reviews. Nephrology·Ali-Reza BiglarniaBo Nilsson
Jun 4, 2015·Journal of the American Society of Nephrology : JASN·Jeffrey B HodginRoger C Wiggins
Aug 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brandon RennerJoshua M Thurman
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H SekineG S Gilkeson
Jul 1, 1994·European Journal of Immunology·I NakanishiM Matsumoto
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·John J NearyMichelle P Winn

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