PMID: 9437728Jan 1, 1997Paper

Localization of endomorphin-2-like immunoreactivity in the rat medulla and spinal cord

Peptides
S Martin-SchildA J Kastin

Abstract

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are endogenous ligands that have greater affinity and selectivity for the mu-opiate receptor than any other known mammalian peptide. A polyclonal antiserum, screened for specificity to endomorphin-2 by immunodot-blot assay and preabsorption controls, was used for localization of this peptide. Immunocytochemistry performed on the brainstem, spinal cord, and sensory ganglia of rats by the avidin-biotin-peroxidase method revealed a continuous dense aggregation of endomorphin-2-like immunoreactive varicose fibers in the superficial laminae of the dorsal horn of the medulla and spinal cord. Immunoreactive fibers were detected in the dorsal root as well as within the dorsal root ganglia. The results suggest that endomorphin-2 is synthesized in primary sensory neurons in ganglia, transported to the superficial dorsal horn, and released near neurons expressing mu receptors. Its distribution appears to represent a functional unit likely to be associated with modulation of nociceptive stimuli.

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Citations

Feb 24, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Pao-Luh TaoEagle Yi-Kung Huang
Mar 17, 1999·European Journal of Pharmacology·B PrzewłockaR Przewłocki
Aug 22, 2001·Peptides·E BujdosóG Telegdy
Sep 10, 2002·Peptides·Csaba TömbölyGéza Tóth
Jan 8, 1999·Peptides·S Martin-SchildJ E Zadina
Apr 27, 2000·Journal of Chemical Neuroanatomy·T L Pierce, M W Wessendorf
Oct 18, 2002·The European Journal of Neuroscience·C AbbadieG W Pasternak
Feb 17, 2000·Annals of the New York Academy of Sciences·J E ZadinaX Zhang
Feb 17, 2000·Annals of the New York Academy of Sciences·G A Barr, J E Zadina
Feb 17, 2000·Annals of the New York Academy of Sciences·R PrzewłockiG Toth
Feb 17, 2000·Annals of the New York Academy of Sciences·H C ChampionP J Kadowitz
Oct 6, 2011·The Journal of Pharmacology and Experimental Therapeutics·Sumita ChakrabartiAlan R Gintzler
Jun 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·S E ForanR M Kream
May 18, 2000·Journal of Neuroimmunology·D S JessopF M De Bree
Oct 8, 2003·British Journal of Pharmacology·Su-Ying WuNae J Dun

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