Localization of equilibrative nucleoside transporters in the rat brain

Journal of Chemical Neuroanatomy
Lauri AlankoSeppo Soinila

Abstract

Adenosine is a recognized inhibitory neuromodulator and neuroprotective agent in the central nervous system. It is produced both intra- and extracellularly and transported across the cell membrane. Nucleoside transporters thus have a major impact on the extracellular adenosine levels, and consequently adenosine signalling. We have raised and characterized polyclonal antibodies against both the equilibrative nucleoside transporters 1 and 2, and report for the first time their distribution in rat brain at the cellular level. Double staining studies were performed to assess the localization of the transporters in neural and glial cells. Both transporters were present in practically all neurons. Some astrocytes showed equilibrative nucleoside transporter 1 staining, while equilibrative nucleoside transporter 2 staining on astrocytes was observed only sporadically.

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Citations

Mar 21, 2007·Pharmaceutical Research·Reynold Spector, Conrad E Johanson
Feb 7, 2013·Neurochemistry International·Eleonora AronicaDetlev Boison
Jul 28, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mary Beth GenterNathan J Cherrington
Oct 6, 2015·Trends in Pharmacological Sciences·James S BrodieGeoffrey W Guy
Apr 8, 2014·Neurochemistry International·Alexandre Dos Santos-RodriguesImogen R Coe
Jan 24, 2018·Frontiers in Neuroscience·Sergi FerréDiego García-Borreguero
Feb 13, 2008·Physiology·Jennifer B Rose, Imogen R Coe
Jul 20, 2018·Journal of Caffeine and Adenosine Research·David BlumPatrizia Popoli
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joana I GomesSandra H Vaz

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