Localization of equilibrative nucleoside transporters in the rat brain

Journal of Chemical Neuroanatomy
Lauri AlankoSeppo Soinila


Adenosine is a recognized inhibitory neuromodulator and neuroprotective agent in the central nervous system. It is produced both intra- and extracellularly and transported across the cell membrane. Nucleoside transporters thus have a major impact on the extracellular adenosine levels, and consequently adenosine signalling. We have raised and characterized polyclonal antibodies against both the equilibrative nucleoside transporters 1 and 2, and report for the first time their distribution in rat brain at the cellular level. Double staining studies were performed to assess the localization of the transporters in neural and glial cells. Both transporters were present in practically all neurons. Some astrocytes showed equilibrative nucleoside transporter 1 staining, while equilibrative nucleoside transporter 2 staining on astrocytes was observed only sporadically.


Feb 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S SoinilaJ Soinila
Oct 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H K WolfI Blümcke
Dec 1, 1996·Brain Research. Molecular Brain Research·C M AndersonF E Parkinson
Jul 3, 1998·European Journal of Pharmacology·J Sawynok
Jun 3, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C E CassS A Baldwin
Jun 4, 1999·European Journal of Pharmacology·D K von Lubitz
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·A HuberD Boison
Nov 21, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Miguel A CabritaCarol E Cass
Jan 18, 2003·Sleep Medicine Reviews·Tarja Porkka-HeiskanenDag Stenberg
Feb 11, 2003·Progress in Neurobiology·J A RibeiroA de Mendonça
Jul 3, 2003·Pflügers Archiv : European journal of physiology·Stephen A BaldwinJames D Young

❮ Previous
Next ❯


Mar 21, 2007·Pharmaceutical Research·Reynold Spector, Conrad E Johanson
Feb 7, 2013·Neurochemistry International·Eleonora AronicaDetlev Boison
Jul 28, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mary Beth GenterNathan J Cherrington
Oct 6, 2015·Trends in Pharmacological Sciences·James S BrodieGeoffrey W Guy
Apr 8, 2014·Neurochemistry International·Alexandre Dos Santos-RodriguesImogen R Coe
Jan 24, 2018·Frontiers in Neuroscience·Sergi FerréDiego García-Borreguero
Feb 13, 2008·Physiology·Jennifer B Rose, Imogen R Coe
Jul 20, 2018·Journal of Caffeine and Adenosine Research·David BlumPatrizia Popoli
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joana I GomesSandra H Vaz

❮ Previous
Next ❯

Related Concepts

Related Feeds


Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.