PMID: 7537729Dec 1, 1994Paper

Localization of F-actin and fodrin along the organ of Corti in the chinchilla

Hearing Research
G AttanasioD Henderson

Abstract

The distribution of the two cytoskeletal proteins, filamentous actin (F-actin) and fodrin, was investigated along the organ of Corti of the chinchilla using laser scanning confocal fluorescence microscopy. High intensity labeling of F-actin was seen in outer and inner hair cells, including the stereocilia. High intensity staining was also seen for fodrin in outer and inner hair cells, but not in their stereocilia. Staining intensity of both proteins along the lateral cell wall of the outer hair cells appeared to be greater in the middle and basal cochlear turns than in the apical turn. Pillars and Deiters cells also exhibited high intensity labeling of F-actin. The lack of significant differences in the distribution of fodrin between outer and inner hair cells makes the role of this protein in the active processes still unclear. Comparison of the distribution of F-actin and fodrin in the chinchilla with those reported in the guinea pigs suggest possible species differences.

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Citations

Mar 8, 2003·International Journal of Pediatric Otorhinolaryngology·Masa-aki Teranishi, Tsutomu Nakashima
Jun 6, 2003·Brain Research Bulletin·Yehoash Raphael, Richard A Altschuler
Dec 22, 2000·Hearing Research·M TeranishiT Wakabayashi
Aug 10, 2004·The Journal of Comparative Neurology·Sabine LadrechMarc Lenoir
Nov 14, 1997·Acta Oto-laryngologica·M Hultcrantz, M L Spångberg

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