PMID: 16617195Apr 18, 2006Paper

Localization of FGF-6 and FGFR-4 during prenatal and early postnatal development of the mouse sublingual gland

Journal of Oral Science
Toshitomo Uehara

Abstract

A number of fibroblast growth factors (FGFs) are involved in regulatory mechanisms of the salivary gland development. However, the role of FGF-6 unique in myogenic cells has not been elucidated in the developing sublingual gland. In the present study, temporo-spatial expression of FGF-6 and its receptor (FGFR)-4, in conjunction with some related histo-chemical properties, were investigated in the sublingual gland of the prenatal and early postnatal mice. The earliest expression of both FGF-6 and FGFR-4 was detected in immature acinar cells at gestational day 17 (GD17). The staining intensity increased gradually and some acinar cells showed a distinct staining at postnatal day 0 (PD0). The immunopositive cells had a relatively round profile and were assumed to be acinar cells. The positive staining decreased thereafter and disappeared completely by PD11. To confirm the identity of cells positive for FGF-6, double immunolabeling with anti-alphasmooth muscle actin (alphaSMA) and anti-FGF-6 antibodies was performed. The positive staining of alphaSMA, a marker of myoepithelial cells, was detected in the flattened cells surrounding the acini but not in the cells positive for FGF-6. The staining properties of secretory granules in aci...Continue Reading

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Citations

Aug 6, 2011·Journal of Molecular Histology·Marit H AureHilde K Galtung
Jul 18, 2012·Journal of Molecular Histology·Hiroshi ShiratsuchiYoshiyuki Yonehara
Aug 3, 2010·Tissue Engineering. Part C, Methods·Adi YanivAaron Palmon

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