Localization of GABA- and GAD-like immunoreactivity in the turtle retina

Visual Neuroscience
L B Hurd, W D Eldred

Abstract

gamma-aminobutyric acid (GABA) has been reported to be an important neurotransmitter in the retinas of many species. This immunocytochemical study detailed the localization of antigens resembling GABA and glutamic acid decarboxylase (GAD, an enzyme involved in the synthesis of GABA), in retinal neurons in the turtle, Pseudemys scripta elegans. GABA-like immunoreactivity was present within somata in the inner and outer regions of the inner nuclear layer, within somata in the ganglion cell layer, and in processes in the outer plexiform layer, inner plexiform layer, and ganglion cell axon layer. GAD-like immunoreactivity was found in somata in the inner and outer regions of the inner nuclear layer and in processes in the inner and outer plexiform layers. Cell counts indicated more somata with GABA-like than GAD-like immunoreactivity in the inner nuclear layer. Double-label studies showed that every somata in the inner nuclear layer which had GAD-like immunoreactivity also had GABA-like immunoreactivity, but that many somata had only GABA-like immunoreactivity. The stratification of immunoreactivity within the inner plexiform layer was analyzed using a scanning densitometer. We described the strate within the inner plexiform layer ...Continue Reading

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C BrandonJ Y Wu
Dec 15, 1978·The Journal of Comparative Neurology·H F Leeper
Jul 1, 1987·Experimental Eye Research·M K Ryan, A E Hendrickson
Jan 26, 1988·Brain Research·B C YuK R Fry
Jan 1, 1987·Histochemistry·E AgardhJ Y Wu
Jun 1, 1986·Experimental Eye Research·J L MosingerK M Studholme
Aug 13, 1986·Brain Research·R J WentholdR A Altschuler
Oct 22, 1985·The Journal of Comparative Neurology·J L Mosinger, S Yazulla
Feb 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W D EldredS Yazulla
Apr 1, 1983·Journal of Neurochemistry·D C SpinkD L Martin
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y NakamuraP Sterling
Mar 20, 1981·The Journal of Comparative Neurology·J E VaughnC E Ribak
Sep 25, 1981·Molecular and Cellular Biochemistry·J Y WuD M Lam

❮ Previous
Next ❯

Citations

Mar 13, 1995·The Journal of Comparative Neurology·C J TylerG J Devries
Oct 21, 2003·The Journal of Comparative Neurology·Mark PottekReto Weiler
Sep 1, 1992·Visual Neuroscience·L R Britto, D E Hamassaki-Britto
Dec 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D M Sherry, S Yazulla
Nov 1, 1991·Visual Neuroscience·J F MullerH Kolb
Jul 1, 1995·Visual Neuroscience·M Bennis, C Versaux-Botteri
Jul 1, 1994·Visual Neuroscience·M KalloniatisR E Marc
May 11, 2000·The Journal of Comparative Neurology·L T Nguyen, N M Grzywacz
Jul 18, 2003·Journal of Neuroscience Research·M BennisR Ward
Feb 1, 2005·The Journal of Comparative Neurology·Dou Yu, William D Eldred
Dec 15, 2015·PLoS Biology·Richard H Kramer, Christopher M Davenport
Jan 7, 1998·The Journal of Comparative Neurology·S HaverkampJ Ammermüller
Jun 18, 2002·Acta Biologica Hungarica·Katalin RáblR Gábriel
Sep 25, 2002·Physiological Reviews·E A Schwartz
Mar 15, 2001·Neurochemistry International·D V Pow
Nov 8, 1991·The Journal of Comparative Neurology·D E Hamassaki-BrittoK T Keyser
Dec 15, 1993·The Journal of Comparative Neurology·Q Liu, E A Debski
Oct 22, 1991·The Journal of Comparative Neurology·A Yaqub, W D Eldred

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.