PMID: 11908871Mar 23, 2002Paper

Localization of gelatinase activities in glioma tissues by film in situ zymography

Brain Tumor Pathology
S TakanoT Nose

Abstract

Malignant gliomas are characterized by their invasiveness and angiogenesis, which are mediated by metalloproteinases (MMPs). In this study, localization of gelatinase activities in six cases of glioblastoma, two cases of anaplastic astrocytoma, and six cases of low-grade astrocytomas was investigated by film in situ zymography (FIZ). FIZ is a novel technique, because it allows preservation of tissue structure with gelatinolytic activity and can detect net MMP activity in tumor tissues. In malignant gliomas, gelatinolytic activities were extensively localized in the vessel walls in the viable tumor areas and peritumoral areas as well as the tumor cell itself. These findings suggest that FIZ is a useful tool not only to detect tumor net MMP activities but also to detect angiogenic features in the invading front of malignant gliomas.

References

Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S K ChintalaJ S Rao
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Apr 17, 2001·Neuro-oncology·S A RaithathaP A Forsyth

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Citations

Feb 6, 2004·Brain Tumor Pathology·Katsuzo KunishioSeigo Nagao
Apr 18, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J X ZhaoX J Pei
Aug 25, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Akira FujiwaraNariaki Matsuura
Sep 25, 2004·Journal of Cellular Physiology·Thomas LudwigVolker Senner

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