Localization of genes controlling resistance to trypanosomiasis in mice

Nature Genetics
S J KempA J Teale

Abstract

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause "sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain is relatively resistant and the A/J (A) and Balb/c (B) strains are susceptible. Such resistance is also well described among several types of west African cattle. We report here the results of genome-wide scans for genes controlling this trait in the B6 mouse using crosses with two different susceptible strains. Regions on mouse chromosomes 5 and 17 were found to be important in determining resistance in both crosses while an additional region on chromosome 1 showed evidence of involvement in only one cross. We confirmed the size of the effect due to chromosome 17 in F3 intercross populations fixed for alternative parental chromosomes. The three loci are of large effect and account for most of the genetic variation in both F2 populations. We propose that they be designated Tir1, Tir2 and Tir3.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M R Rifkin
Dec 1, 1979·Experimental Parasitology·W I Morrison, M Murray
Aug 1, 1981·Infection and Immunity·J W Albright, J F Albright
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K G LarkJ H Orf
Mar 14, 1996·Nature·W F DietrichT J O'Connor
Mar 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A Darvasi

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Citations

Apr 30, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·O Delphin KoudandéFuad Iraqi
Jun 20, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jerzy M BehnkeJohn P Gibson
May 17, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David CourtinAndré Garcia
Apr 6, 2005·Veterinary Immunology and Immunopathology·Dirk-Jan de KoningChris S Haley
Oct 17, 2006·Parasitology Today·S J Kemp, A J Teale
Dec 13, 2000·Microbes and Infection·H TabelJ E Uzonna
Feb 7, 2008·Heredity·O D KoudandéJ A M van Arendonk
May 13, 1999·Immunological Reviews·S A Ellis, K T Ballingall
Jan 21, 2010·Infection and Immunity·Liam J MorrisonC Michael R Turner
Dec 4, 2009·PLoS Neglected Tropical Diseases·Liam J MorrisonAnnette MacLeod
Jun 15, 2011·PLoS Neglected Tropical Diseases·Matyáš SímaMarie Lipoldová
Jun 22, 2012·PLoS Neglected Tropical Diseases·Vincent JamonneauBruno Bucheton
Apr 15, 2009·PloS One·Harry A NoyesJan Naessens
Jun 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·O HanotteA Teale
Dec 9, 2015·Trends in Parasitology·David BerthierBruno Bucheton
May 17, 2011·Veterinary Parasitology·Andy TaitAnnette Macleod
Aug 8, 2008·Trends in Parasitology·Nicolas Antoine-MoussiauxDaniel Desmecht
Apr 9, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David CourtinBruno Bucheton
Mar 18, 2005·Parasite Immunology·J M Sternberg
Oct 8, 2008·Immunological Reviews·Henry TabelMeiqing Shi
Mar 4, 2011·Parasite Immunology·L J Morrison
May 25, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David CourtinAndré Garcia
May 10, 2006·Experimental Parasitology·Kum Kum BhasinAldons J Lusis
Apr 2, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David CourtinAndré Garcia
Oct 20, 2007·Trends in Biotechnology·Dirk-Jan de KoningChris S Haley

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African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

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