PMID: 9527540Apr 4, 1998Paper

Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system

The Journal of Comparative Neurology
G W GlaznerJ E Springer

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that influences the survival and function of several neuronal populations in the central (CNS) and peripheral nervous systems. The actions of GDNF are mediated by a multicomponent receptor complex composed of the tyrosine kinase product of c-ret and the ligand-binding protein GDNF receptor alpha (GDNFR-alpha). In the present study, we used in situ hybridization to localize cells expressing the mRNA for these GDNF receptor subunits in rat CNS. As reported previously, GDNFR-alpha and c-ret mRNA are present in the substantia nigra and ventral tegmental area, regions containing GDNF-responsive dopamine neurons. However, both mRNA were found in motor neurons of spinal cord and brainstem nuclei that innervate skeletal muscle. These areas include alpha motor neurons in the ventral horn of spinal cord and neurons in hypoglossal, facial, trigeminal, and abducens nuclei. In areas rostral to the substantia nigra, c-ret mRNA is not detected, whereas GDNFR-alpha is found in numerous brain structures, including the hippocampus, cortex, medial geniculate, and the medial habenula, the latter area expressing the highest levels of GDNFR-alpha mRNA in brain. These results...Continue Reading

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Citations

Jan 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dao-Yao HeDorit Ron
Sep 18, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Masatoshi SuzukiClive N Svendsen
Nov 17, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Anja DrinkutSebastian Kügler
Mar 30, 2010·Journal of Chemical Neuroanatomy·Phalguni Anand AlladiUday Muthane
Jan 13, 2009·Pharmacology & Therapeutics·Sebastien Carnicella, Dorit Ron
Sep 2, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Tanja M MichelEdna Grünblatt
Mar 24, 2009·Alcoholism, Clinical and Experimental Research·Sebastien CarnicellaDorit Ron
Nov 1, 2008·The European Journal of Neuroscience·Vandana ZamanLawrence D Middaugh
Dec 22, 2006·The Journal of Comparative Neurology·Joost L M JongenJan C Holstege
Jul 9, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Maria Pina SerraMarina Del Fiacco
Apr 2, 1999·The European Journal of Neuroscience·Z KokaiaM Saarma
Dec 22, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H KitagawaK Abe
Oct 7, 2003·The Journal of Comparative Neurology·Yasuyoshi ArimatsuAkira Omori
Jan 28, 2003·Journal of Neuroscience Research·Gita PezeshkiJürgen Engele

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