PMID: 9163782May 1, 1997Paper

Localization of glutamate receptor subunits of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) type in the pancreas of newborn guinea pigs

Pancreas
H P LiuS K Leong

Abstract

Glutamate and related molecules are the major excitatory neurotransmitters in the central nervous system, and their receptors have been localized therein. Little is, however, known about them in the peripheral nervous system. The present study investigated the localization of glutamate receptor subunits of the alpha-amino-3-hydroxy- 5-methyl-4-isoxazolepropionate (AMPA) type (GluR1, GluR2-3, and GluR4) in the pancreas of newborn guinea pigs. With a double-labeling method of immunofluorescence and immuno-tetrahydrochloride reaction, GluR1 and GluR4 immunoreactivities were localized mostly in the insulin-secreting cells in the central mass of the islet, and GluR2-3 immunoreactivity in the peripheral rim of the islet, which consists mainly of non-insulin-secreting islet cells. With a double-labeling method employing immunofluorescence and NADPH-diaphorase (NADPH-d) histochemistry, GluR2-3 and GluR4 immunoreactivities were localized in most of the NADPH-d positive pancreatic ganglion cells. None of the NADPH-d-positive ganglion cells showed GluR1 immunoreactivity. In fact, GluR1 immunoreactivity was not detected in any of the pancreatic ganglion cells. The results indicate that glutamate is likely to exert its effects on the pancre...Continue Reading

Citations

Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Liqun BaiFayez K Ghishan
Nov 26, 2005·Expert Opinion on Investigational Drugs·Niki KalaritiMichael Koutsilieris
Dec 23, 2003·European Journal of Biochemistry·Eiichi HinoiYukio Yoneda
Mar 29, 2005·World Journal of Gastroenterology : WJG·Tao LiLiqun Bai
Jun 10, 2015·Journal of Receptor and Signal Transduction Research·Colin G Rousseaux, Stephanie F Greene
Sep 5, 2002·Nature Reviews. Neuroscience·Maiken NedergaardAnker J Hansen
Jan 12, 2000·Free Radical Research·S K Leong
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Qingchun TongAnnette L Kirchgessner
Jan 24, 2012·Biochemical and Biophysical Research Communications·Mohammed FarooqPeter H Frederikse
May 23, 2001·Progress in Neurobiology·N C Danbolt

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