Localization of GnRH molecular forms in the brain, pituitary, and testis of the frog, Rana esculenta

The Journal of Experimental Zoology
L Di MatteoR Pierantoni

Abstract

In the amphibian brain four molecular forms of GnRH have been identified so far: mammalian GnRH (m- and hydroxyproline9m-), chicken II GnRH (cII), and a salmon (s) GnRH-like peptide. In Rana esculenta, cII- and s-GnRH-like molecules have been partially characterized in the brain extracts using HPLC combined with radioimmunoassay. Moreover, since cII-GnRH-like material has been detected in Rana esculenta testis, the present study describes the localization of the above peptides in the brain and testis of the frog. Immunoreactive cII-GnRH and m-GnRH neurons and fibers were identified in the anterior preoptic area (APOA) and in the median septal area (MSA). A population of cells located on the dorsal side of the caudal preoptic region was also stained. Immunopositive fibers were seen to overlap the median eminence before ending within the pars nervosa. Moreover, densely packed fibers made close contact with the vascular complex in the median eminence. Conversely, immunoreactive s-GnRH-like material was absent in APOA and MSA, but weakly scattered elements were detected by the anti-s-GnRH serum in the dorsal side of the caudal preoptic region. Using m-GnRH antiserum, a strong immunopositivity was observed in the median eminence but...Continue Reading

References

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Citations

Jun 18, 1998·Annals of the New York Academy of Sciences·M VallarinoH Vaudry
Jun 18, 1998·Annals of the New York Academy of Sciences·S FasanoR Pierantoni
Nov 21, 2015·Molecular and Cellular Endocrinology·Vincenza CiaramellaRosanna Chianese
Sep 11, 2009·Trends in Endocrinology and Metabolism : TEM·Lazar Z KrsmanovicKevin J Catt
Mar 8, 2008·Molecular and Cellular Endocrinology·Rosanna ChianeseRosaria Meccariello
Nov 23, 2007·General and Comparative Endocrinology·George E BentleyKazuyoshi Tsutsui
May 22, 2009·Annals of the New York Academy of Sciences·Silvia FasanoRiccardo Pierantoni
Dec 3, 2014·General and Comparative Endocrinology·Rosanna ChianeseRosaria Meccariello
Aug 2, 2011·General and Comparative Endocrinology·Rosanna ChianeseRosaria Meccariello
Sep 28, 2013·International Journal of Endocrinology·Rosanna ChianeseRosaria Meccariello
Apr 11, 2008·The Journal of Comparative Neurology·Meng YaoRobert J Denver
Jun 7, 2012·American Journal of Physiology. Endocrinology and Metabolism·Rosanna ChianeseRosaria Meccariello
Mar 1, 2000·Endocrinology·Lazar Z KrsmanovicKevin J Catt
Aug 4, 1998·Journal of Neuroendocrinology·A Gobbetti, M Zerani

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