Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosome

Histochemistry and Cell Biology
Haruo HagiwaraKuniaki Takata

Abstract

In vertebrate cells, the centrosome consists of a pair of centrioles and surrounding pericentriolar material. Using anti-Golgi 58K protein antibodies that recognize formiminotransferase cyclodeaminase (FTCD), we investigated its localization to the centrosome in various cultured cells and human oviductal secretory cells by immunohistochemistry. In addition to the Golgi apparatus, FTCD was localized to the centrosome, more abundantly around the mother centriole. The centrosome localization of FTCD continued throughout the cell cycle and was not disrupted after Golgi fragmentation, which was induced by colcemid and brefeldin A. Centriole microtubules are polyglutamylated and stable against tubulin depolymerizing drugs. FTCD in the centrosome may be associated with polyglutamylated residues of centriole microtubules and may play a role in providing centrioles with glutamate produced by cyclodeaminase domains of FTCD.

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Citations

Dec 7, 2006·Histochemistry and Cell Biology·Douglas J TaatjesJürgen Roth
Nov 1, 2007·Histochemistry and Cell Biology·Christian ZuberJürgen Roth
Dec 25, 2008·Medical Molecular Morphology·Haruo HagiwaraKuniaki Takata
May 15, 2010·The Journal of Biological Chemistry·Zhe WangRobert Z Qi
Aug 24, 2010·Journal of Negative Results in Biomedicine·Frances K WisemanElizabeth M C Fisher
Jan 29, 2008·Acta Histochemica Et Cytochemica·Takeshi SuzukiKuniaki Takata
Jun 19, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shigeki AokiHiroshi Suzuki
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Gianni Guizzunti, Joachim Seemann
Sep 3, 2014·Chembiochem : a European Journal of Chemical Biology·Neda NasheriJohn Paul Pezacki

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