PMID: 19912847Feb 1, 1992Paper

Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization

Molecular and Cellular Neurosciences
H A JinnahT Friedmann

Abstract

Congenital deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) in humans results in a severe neurogenetic disorder known as the Lesch-Nyhan syndrome. Since little information concerning the precise localization of HPRT in the brain is currently available, we have used in situ hybridization to examine the expression of HPRT mRNA in the mouse brain. The results showed that HPRT mRNA is expressed in many regions of the normal mouse brain, with high levels in most, but not all neurons. In contrast, glial cells did not express detectable levels of HPRT mRNA. No HPRT mRNA was detected in the brains of mutant mice carrying a deletion in the HPRT gene.

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Citations

Apr 13, 2000·Brain Research. Brain Research Reviews·J E VisserH A Jinnah
Jun 1, 1993·Journal of Neurochemistry·H A JinnahT Friedmann
Mar 22, 2007·Neurobiology of Disease·Kiyoshi EgamiH A Jinnah
May 22, 2016·Journal of the Neurological Sciences·Sarah K TschirnerVolkhard Kaever
Mar 15, 2015·Molecular Genetics and Metabolism·Eric B DammerH A Jinnah
Aug 27, 2013·Brain : a Journal of Neurology·Rong FuUNKNOWN Lesch-Nyhan Disease International Study Group
Apr 6, 2004·The Psychiatric Clinics of North America·Stephen V Faraone
Dec 23, 2008·Biochemical and Biophysical Research Communications·Misaki KojimaMasakuni Degawa
Mar 4, 2006·Clinical Psychology Review·Irwin D Waldman, Ian R Gizer
May 17, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shaochun Song, Theodore Friedmann
Aug 6, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M OrdwayP J Detloff
Feb 1, 2007·Metabolic Brain Disease·Doug W Smith, Hyder A Jinnah
Mar 5, 2009·Disease Models & Mechanisms·H A Jinnah
Apr 21, 2021·Scientific Reports·Diane J SutcliffeH A Jinnah

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