PMID: 4900926Dec 1, 1969Paper

Localization of immunological complexes fixing beta1C (C3) in germinal centers of lymph nodes

The Journal of Experimental Medicine
K J Gajl-PeczalskaR A Good

Abstract

28 human and 60 experimentally stimulated rabbit lymph nodes were studied by means of light microscopy and immunofluorescence. 21 of the 28 human lymph nodes showed well-developed germinal centers. IgM, IgG, and the beta(1C) component of complement were found in the same distribution within germinal centers when examined in serial cryostat sections. 36 rabbits were stimulated with Brucella antigen, and 24 rabbits with BSA. A strikingly consistent correlation between distribution and appearance of specific staining for rabbit beta(1C), IgM, and IgG was observed; when lymph nodes were stimulated with BSA, antigen and specific antibody were present. Treatment of unfixed sections with citrate-buffered saline at low pH resulted in complete elution of immunoglobulins, beta(1C), and BSA from rabbit germinal centers, and in marked diminution of IgG and IgM in human germinal centers, while at the same time plasma cells remained strongly fluorescent. Specific selective fixation of heterologous (human) complement in rabbit germinal centers positive for beta(1C), IgG, IgM, and BSA was also obtained. These data present strong evidence for the existence within germinal centers of antigen-antibody complexes which fix at least the beta(1C) com...Continue Reading

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Citations

Dec 1, 1987·Immunology Letters·M DexterE Timms
Mar 1, 1973·The Journal of Experimental Medicine·S M MauerA F Michael
Jan 1, 1973·Scandinavian Journal of Immunology·S Thunold
Jan 1, 1976·Transplantation Reviews·M B Pepys
Mar 1, 1971·The Journal of Clinical Investigation·N G WestbergA F Michael
Nov 1, 1973·The Journal of Clinical Investigation·L W HoyerJ R Hoyer
May 1, 1974·The Journal of Clinical Investigation·J R HoyerL W Hoyer
May 8, 2015·Cell and Tissue Research·Shigeo EkinoSeiji Inui
Oct 1, 1977·The Journal of Dermatology·S InadaT Yamura
Nov 1, 1989·Clinical Immunology and Immunopathology·A MasudaK Oka
May 31, 1972·Nature: New Biology·M B Pepys
Jan 1, 1981·Acta Medica Scandinavica·B SchmekelN G Westberg
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yüksel AydarJohn G Tew
Jan 21, 2021·Frontiers in Immunology·Andy DernstedtMattias N E Forsell

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