PMID: 11912287Mar 26, 2002Paper

Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta

Molecular Human Reproduction
P SedlmayrG Dohr

Abstract

Indoleamine 2,3-dioxygenase (IDO) has been implicated in regulation of feto-maternal tolerance and protection against intracellular and extracellular pathogens. We have studied the expression of IDO in the human female reproductive tract and the placenta by immunohistochemistry. Endometrial glandular and surface epithelial cells showed increasing IDO expression during the course of the menstrual cycle. In term placenta, IDO was irregularly localized to the mesenchymal core and found in isolated areas of the syncytiotrophoblast. In first trimester pregnancy, IDO was not present in placental villi, but was present in glandular epithelium of the decidua, and there were distinctly positive cells scattered in the connective tissue, sometimes in conjunction with lymphoid aggregates. The endothelium of spiral arteries and of capillaries showed some, albeit no generalized, reactivity. IDO was also present in the epithelium of cervical glands and of Fallopian tubes. Specificity of antibody binding was confirmed by Western blot analysis. IDO mRNA was detected in first trimester decidua as determined by RT-PCR. IDO is secreted, as determined by analysis of cervical mucus by high pressure liquid chromatography for the presence of the trypt...Continue Reading

Citations

Jun 22, 2012·Wiener medizinische Wochenschrift·Peter Sedlmayr, Astrid Blaschitz
Sep 11, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xiangchen Dai, Bao Ting Zhu
Jan 31, 2013·Biochimica Et Biophysica Acta·C BhaskarAnand K Kondapi
Aug 9, 2005·Expert Opinion on Therapeutic Targets·Alexander J MullerGeorge C Prendergast
Dec 1, 2007·Expert Opinion on Medical Diagnostics·Pankaj SinghalKunle Odunsi
May 5, 2009·Journal of Reproductive Immunology·M Jeddi-TehraniA H Zarnani
Apr 23, 2004·The Journal of Investigative Dermatology·Aziz GhaharyXiaoyue Lin
Oct 24, 2008·Veterinary Microbiology·Gary EntricanNicholas Wheelhouse
May 21, 2008·Journal of Reproductive Immunology·Jessica G DrenzekThaddeus G Golos
Apr 12, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Estibaliz AlegreAlvaro González
Dec 7, 2007·The American Journal of Pathology·Marina SchelerDagmar von Bubnoff
Sep 21, 2007·Seminars in Cancer Biology·Nathalie Rouas-FreissEdgardo D Carosella
Feb 27, 2007·Journal of Reproductive Immunology·U von RangoI Classen-Linke
Oct 21, 2004·American Journal of Reproductive Immunology : AJRI·Shalini C LoboLinda C Giudice
Feb 28, 2003·Clinical and Experimental Immunology·J HeikkinenO Lassila
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·A Sindram-TrujilloF Claas
Jan 30, 2004·American Journal of Reproductive Immunology : AJRI·Kristijan CupurdijaPeter Sedlmayr
Nov 27, 2008·American Journal of Reproductive Immunology : AJRI·Antonis MakrigiannakisAris Antsaklis
Jul 20, 2010·Immunological Reviews·Philippa MarrackMegan K L MacLeod
Apr 6, 2004·Journal of Reproductive Immunology·Yoshiki KudoI L Sargent
Jun 21, 2006·Seminars in Fetal & Neonatal Medicine·Kjersti M Aagaard-TilleryJess Dalton
May 10, 2006·Seminars in Fetal & Neonatal Medicine·Ole B ChristiansenAstrid M Kolte
Oct 21, 2005·Journal of Reproductive Immunology·Margaret G Petroff
Nov 15, 2006·Cellular & Molecular Biology Letters·Derin B KeskinDebra A Gearhart
Jul 16, 2004·The Journal of Clinical Investigation·Tomoko HayashiEyal Raz
Jun 15, 2011·Medical Hypotheses·Alok BangaDaniel F Connor
Nov 20, 2014·In Vitro Cellular & Developmental Biology. Animal·Dang-Dang LiZhan-Peng Yue
Feb 19, 2015·Frontiers in Immunology·Nicolas van Baren, Benoît J Van den Eynde
Jun 7, 2014·Frontiers in Immunology·Peter SedlmayrRoland Stocker
May 26, 2016·The Journal of Allergy and Clinical Immunology·Maria C MagnusWenche Nystad
Oct 31, 2007·Clinics in Plastic Surgery·Mayer Tenenhaus, Hans Oliver Rennekampff
Jul 13, 2013·The Journal of International Medical Research·Yanli BanXun Qu
Jan 23, 2014·Journal of Psychopharmacology·Abdulla A-B Badawy
Jan 6, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Rie KawaguchiTadao Tanaka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.