PMID: 8948288Nov 1, 1996Paper

Localization of insulin-like growth factor-1 receptor in human normal and osteoarthritic cartilage in relation to proteoglycan synthesis and content

British Journal of Rheumatology
P J VerschureW B Berg

Abstract

Insulin-like growth factor-1 (IGF-1) plays a key role in the regulation of chondrocyte proteoglycan (PG) metabolism. We investigated whether chondrocyte PG synthetic activity correlates with the presence of chondrocyte IGF-1 receptor in the surface, middle and deeper zones of normal human articular cartilage and in cartilage known to display a shift in chondrocyte metabolism, i.e. cultured cartilage or osteoarthritic (OA) cartilage. Cartilage specimens were obtained post mortem from human knees within 18 h after death from donors without known clinical OA history. The samples were taken from macroscopically normal looking regions as well as from damaged regions with osteoarthritic appearance, yielding a range of OA grades from mild to moderate and severe OA. We examined chondrocyte PG synthesis by in situ autoradiography of incorporated [35S]sulphate and chondrocyte IGF-1 receptor localization by immunohistochemistry, followed by confocal laser scanning microscopical (CLSM) analysis in the same cartilage samples. In normal cartilage, both the amount of chondrocyte PG synthesis and the level of chondrocyte IGF-1 receptor localization are at low levels in the surface zone chondrocytes, but both are high in middle and deeper zone ...Continue Reading

Citations

Mar 17, 2005·Rheumatology International·Tania SilvestriRiccardo Meliconi
Apr 7, 2010·Metabolic Syndrome and Related Disorders·Manuel T Velasquez, James D Katz
Jul 27, 2011·Connective Tissue Research·Anika JonitzRainer Bader
Dec 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Teresa I Morales
Nov 24, 1999·Osteoarthritis and Cartilage·D PfanderB Swoboda
Nov 26, 2013·Osteoarthritis and Cartilage·Y AkasakiM K Lotz
Aug 28, 2018·Tissue Engineering. Part a·Seyedsina MoeinzadehEsmaiel Jabbari
Jul 22, 2005·Annals of Plastic Surgery·Shinichi TeradaJoseph P Vacanti
May 7, 1998·Endocrine Reviews·M Ehrhart-BornsteinG P Vinson
Nov 10, 2005·Rheumatology·G Verbruggen

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