Localization of interferon regulatory factor-1 in human endometrium throughout the menstrual cycle

Fertility and Sterility
K KitayaH Honjo

Abstract

To determine the expression and localization of IRF-1 in human endometrium throughout the menstrual cycle. A comparative study. Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine. Thirty-eight women aged 33 to 46 years, with regular menstrual cycles and nonpathological endometrium, undergoing hysterectomy. Endometrial tissues were obtained from operative samples. Expression of IRF-1 mRNA throughout the menstrual cycle was investigated using semiquantitative reverse transcription-polymerase chain reaction. Localization of IRF-1 protein was determined using immunohistochemistry. IRF-1 mRNA was expressed in the human endometrium at each phase of the menstrual cycle. The immunoreactivity for IRF-1 was observed in the extranuclear compartment of the surface and glandular epithelial cells, both during the proliferative and secretory phases, as well as in the gland secretion during the secretory phase. In contrast, stromal cells were nearly unstained. IRF-1 was localized in the human endometrium, implying that this nuclear protein plays some role other than as a transcription factor.

References

May 10, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P M StarkeyM C Rees
Jan 1, 1996·American Journal of Reproductive Immunology : AJRI·M H LachapelleD C Roy
Jul 7, 1999·American Journal of Reproductive Immunology : AJRI·A FukuiY Saito
Dec 28, 1999·Molecular Human Reproduction·S OkadaH Kanzaki
Aug 23, 2000·Biology of Reproduction·K KitayaH Honjo

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Citations

Nov 6, 2003·Gynecologic Oncology·Haruo KuroboshiHideo Honjo
Jul 31, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·B Anne CroyAureo T Yamada
Oct 21, 2004·American Journal of Reproductive Immunology : AJRI·Shalini C LoboLinda C Giudice
Aug 30, 2013·AIDS Research and Human Retroviruses·Aida SivroT Blake Ball
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Kotaro KitayaHideo Honjo
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali A AshkarB Anne Croy

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