PMID: 8596673Oct 1, 1995Paper

Localization of interleukin-8 in human gingival tissues

Oral Microbiology and Immunology
J E Fitzgerald, D Kreutzer

Abstract

Periodontitis and gingivitis are chronic inflammatory diseases of the periodontium and adjacent tissues. This site-specific inflammation is characterized by a local infiltration of polymorphonuclear leukocytes and T lymphocytes. Interleukin-8 is a low molecular-weight cytokine that is thought to be responsible for the induction and maintenance of localized inflammation. We hypothesized that locally produced interleukin-8 plays a central role in chronic inflammation of periodontitis by regulating the recruitment and activation of leukocytes in the gingival tissues. To test this hypothesis, we determined whether the interleukin-8 antigen is present locally and is cell-associated. Inflamed and control tissues were analyzed: 1) for the interleukin-8 antigen; 2) by molecular weight; 3) for location; and 4) for the messenger RNA (mRNA) of interleukin-8. The conclusions from these data were that: 1) interleukin-8 antigen and mRNA was elevated in chronically inflamed gingiva; and 2) the major interleukin-8 antigen was detected only in the epithelial cell layer. These results support that interleukin-8 may play a crucial role in the recruitment and activation of neutrophils and T lymphocytes in periodontitis.

References

Feb 1, 1975·Journal of Periodontal Research·R AttströmA Sjöholm
Jan 1, 1991·Journal of Periodontology·J J JandinskiM J Deasy
Jan 1, 1990·Cytokine·A J GearingR D Camp
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Citations

Nov 28, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J S AllenD Kreutzer
Jun 1, 1996·Journal of Clinical Periodontology·B von Troil-LindénS Asikainen
Dec 10, 1999·Journal of Periodontology·S SéguierN Brousse
May 18, 1999·Journal of Periodontology
May 5, 2006·Journal of Periodontology·Akihiko SakaiKoichi Ito
May 30, 2014·Journal of Indian Society of Periodontology·Myriam A KossMaria E López
Apr 13, 2010·Anaerobe·Michael KirschbaumSigrun Eick
Oct 10, 2008·Journal of Periodontal Research·M KebschullP N Papapanou
Apr 30, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A BeklenG Tsaous Memet
Aug 26, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G Suchett-KayeO Barsotti
May 22, 1998·The Annals of Otology, Rhinology, and Laryngology·J S AllenD Kreutzer
Mar 27, 2007·Journal of Dental Research·T A SilvaF Q Cunha
Dec 20, 2002·American Journal of Physiology. Cell Physiology·Eisuke F SatoMasayasu Inoue
May 7, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Mahmoud Rouabhia, Noëlla Deslauriers
Mar 27, 2003·Periodontology 2000·Andrew J Delima, Thomas E Van Dyke
Sep 21, 2013·The Journal of Clinical Pediatric Dentistry·D DakovicN Stamatovic
Nov 24, 2020·Periodontology 2000·Luciana Macchion ShaddoxLuigi Nibali
Mar 11, 2021·Periodontology 2000·Ana M ChangRichard P Darveau
Jun 1, 2021·Archives of Oral Biology·Glauber Campos Vale, Marcia Pinto Alves Mayer

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