PMID: 1197943Jun 1, 1975Paper

Localization of irritant receptors in the airways of the dog

Respiration Physiology
J P MortolaM G Clement

Abstract

In dogs the authors have recorded from single fibres of the vagus nerve the action potentials originating from rapidly adapting receptors (irritant receptors) of the tracheo-bronchial tree activated both by inflation and deflation and by i.v. injection of histamine. A gross localization between extrapulmonary airways was established for 196 such receptors by probing the structures containing them. For 82 receptors a precise localization was determined within the extrapulmonary airways and for 51 receptors, localized in the lung parenchyma, a further precise localization was established along the intrapulmonary airways be dissecting the lung tissue. 66.9% of these receptors were found to be in the intrapulmonary airways and 33.1% in the extrapulmonary airways. Their distribution along the tracheo-bronchial tree resulted as follows: 4.75% in the higher 2/3 of the trachea, 9.25% in the lower 1/3 of the trachea and the carina, 19.0% in the main bronchus, 25.0% in the lobar bronchi, 36.8% in bronchi having a diameter larger than 1 mm and 5.2% in bronchi having a diameter smaller than 1 mm. Therefore the concentration of irritant receptors increases going from the upper trachea to the lobar bronchi and then sharply decreases reaching...Continue Reading

References

Dec 1, 1973·The Journal of Physiology·G MiserocchiG Sant'ambrogio
Jun 1, 1973·The Journal of Physiology·A StranskyJ G Widdicombe
Jul 1, 1974·Respiration Physiology·D J Armstrong, J C Luck
Jul 1, 1974·Respiration Physiology·G Miserocchi, G Sant'Ambrogio
Apr 1, 1970·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J G Widdicombe, H Sellick

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Citations

Oct 1, 1984·Agents and Actions·A J Schreurs, F P Nijkamp
Dec 10, 1985·European Journal of Pharmacology·G Folkerts, F P Nijkamp
Nov 1, 1982·Respiration Physiology·J T Fisher, G Sant'Ambrogio
Jan 1, 1982·Respiration Physiology·D R Bergren, S R Sampson
Oct 1, 1984·Respiration Physiology·D E Millhorn, J P Kiley
May 1, 1991·Respiration Physiology·P D Sly, C J Lanteri
Nov 1, 1984·Prostaglandins, Leukotrienes, and Medicine·D R Bergren, D L Myers
Mar 10, 2001·Respiration Physiology·J Widdicombe
Mar 10, 2001·Respiration Physiology·G Sant'Ambrogio, J Widdicombe
Dec 19, 1998·Respiration Physiology·J G Widdicombe
Mar 27, 2003·Pulmonary Pharmacology & Therapeutics·Maria G Belvisi
May 22, 2002·Current Opinion in Pharmacology·Maria G Belvisi
Feb 1, 1978·The Journal of Clinical Investigation·R H StraussJ J Jaeger
Jan 13, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Sara J BonviniMaria G Belvisi
Sep 1, 1980·The Annals of Otology, Rhinology, and Laryngology·T V McCaffrey, E B Kern
Dec 21, 2002·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·John Widdicombe
Jan 1, 1987·Pediatric Pulmonology·A A HutchisonR L Bucciarelli
Aug 22, 1988·The Journal of Comparative Neurology·M Kalia, D Richter
Nov 11, 2017·The Journal of Comparative Neurology·Yoshio Yamamoto, Nobuaki Nakamuta
Dec 15, 2020·Respiratory Physiology & Neurobiology·Jerry Yu
Mar 21, 1980·Journal of Theoretical Biology·J P Mortola, S A Mortola

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