Localization of LewisX, sialyl-LewisX and alpha-galactosyl epitopes on glycosphingolipids in lens tissues

Glycobiology
M OgisoM Hoshi

Abstract

Mammalian lens contains several neutral and acidic glycosphingolipids, the core structures of which are ganglio-, neolacto-, globo-, and isoglobo-series sugar chains. Old World monkey lens shows glycosphingolipid compositions similar to those of human cataractous lens, in particular the presence of Lewisxand sialyl-Lewisxepitopes and the absence of alpha-galactosyl epitope. Dog and pig lenses contain globotriaosylceramide and the sialyl-Lewisxcontaining neolactotetraosylceramide, respectively, which were found in primate lens, together with the alpha-galactosyl epitope containing neolactotetraosylceramide. Thin-layer chromatography immunostaining revealed the enrichment of some neolacto-series glycosphingolipids in the cortical and nuclear fibers, but not in lens epithelia, of dog, pig, and Japanese monkey lenses. Immunohistochemical studies confirmed the expression of Lewisx, sialyl-Lewisx, and alpha-galactosyl epitopes in the inner cortical and nuclear fibers, in association with the differentiation and maturation of lens epithelial cells to lens fibers. Glycobiological approaches thus suggested that some neolacto-series glycosphingolipids are involved in lens fiber development, in which the physiological roles of the alpha-g...Continue Reading

References

Jul 8, 1977·Science·H Bloemendal
May 1, 1975·Experimental Eye Research·T Kuwabara
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M J PolleyJ C Paulson
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·U GaliliB A Macher
Dec 1, 1994·Experimental Eye Research·M OgisoM Hoshi
Mar 1, 1993·The Journal of Cell Biology·D V ErbeL A Lasky
Feb 1, 1995·Experimental Eye Research·M OgisoM Komoto

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Citations

Sep 7, 2011·Age·Jessica R HughesTodd W Mitchell
Sep 25, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M Saito, K Sugiyama
Apr 22, 2010·Journal of Lipid Research·Douglas Borchman, Marta C Yappert

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