Localization of metalloporphyrin-induced "specific" enhancement in experimental liver tumors: comparison of magnetic resonance imaging, microangiographic, and histologic findings

Academic Radiology
Y NiF K Maier

Abstract

We investigated the tumor specificity of gadolinium mesoporphyrin (Gd-MP) and manganese tetraphenylporphyrin (Mn-TPP) as magnetic resonance (MR) imaging contrast agents. Fifteen rats with multiple hepatocellular carcinomas and eight rats with implanted Novikoff hepatomas were given intravenous injections of either Gd-MP or Mn-TPP at 0.05 mmol/kg, which was compared with nonspecific gadopentetate dimeglumine (0.3 mmol/kg). T1-weighted spin-echo images were obtained before and up to 48 hr after injection and compared with corresponding microangiograms and histologic specimens. The relative enhancement of organs and tumors was plotted as a function of time. Initially, both metalloporphyrins behaved as nonspecific agents, similar to gadopentetate dimeglumine, and enhanced the tumor by perfusion and diffusion. However, metalloporphyrins, but not gadopentetate dimeglumine, caused a delayed (> or = 3 hr) enhancement in some compartments of certain lesions. The MR imaging-microangiography-histology matching technique revealed that those compartments were actually nonviable components, including necrosis (n = 10), thrombosis (n = 7), and cystic secretion (n = 3), but not viable tumor tissue. Metalloporphyrins did not prove to be tumor s...Continue Reading

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Citations

Mar 17, 1999·Journal of Magnetic Resonance Imaging : JMRI·B HofmannR Weissleder
Nov 5, 1999·Journal of Magnetic Resonance Imaging : JMRI·M F WendlandC B Higgins
Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yasuo TakeharaIsao Sakata
Jan 14, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Reza GolestaniRiemer H J A Slart
Mar 19, 2005·Abdominal Imaging·Y NiG Marchal
Feb 22, 2012·Targeted Oncology·Junjie LiYicheng Ni
Aug 6, 2000·European Journal of Radiology·M SaeedC B Higgins
Aug 22, 2002·Academic Radiology·Yicheng NiGuy Marchal
May 22, 2002·Academic Radiology·Yicheng NiGuy Marchall
Jul 19, 2005·Investigative Radiology·Yicheng NiGuy Marchal
Oct 20, 2012·Theranostics·Yumiao Zhang, Jonathan F Lovell
Jun 30, 2011·Radiology·Junjie LiYicheng Ni
Feb 2, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Yicheng NiGuy M Bormans
Oct 19, 2011·Investigational New Drugs·Marlein Miranda ConaYicheng Ni
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May 21, 2005·Journal of Magnetic Resonance Imaging : JMRI·Christoph BremerPeter Reimer

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