PMID: 9550147Apr 29, 1998Paper

Localization of mRNA encoding the P2X2 receptor subunit of the adenosine 5'-triphosphate-gated ion channel in the adult and developing rat inner ear by in situ hybridization

The Journal of Comparative Neurology
G D HousleyA F Ryan

Abstract

Localization of expression of the adenosine 5'-triphosphate (ATP)-gated ion channel P2X2 receptor subunit (P2X2R) in the rat inner ear at different stages of development was achieved by using in situ mRNA hybridization. In the adult, P2X2R mRNA was strongly expressed in many of the cells bordering the cochlear endolymphatic compartment. This included the interdental cells of the spiral limbus, all cells of the inner sulcus and organ of Corti, and cells of the spiral prominence. In the vestibular labyrinth, strong expression was noted in the transitional cells at the base of the crista ampullaris and in the sensory epithelium of the crista and maculae. During development, P2X2R mRNA expression was evident in the precursors of these structures at the earliest period studied, embryonic day 12 (E12). Expression increased during the ontogeny in both the cochlear and the vestibular end organs. In addition, both the spiral and vestibular ganglia showed developmental expression. In contrast to the supporting cells of the organ of Corti, both inner and outer hair cells exhibited P2X2R mRNA only after postnatal day 10 (P10) through P12, concomitant with the onset of hearing. P2X2R expression levels in all cells fell from a maximum at P12...Continue Reading

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Citations

Feb 21, 2004·Journal of the Association for Research in Otolaryngology : JARO·Peter R ThorneGary D Housley
Nov 4, 2005·Cell Communication and Signaling : CCS·Daniel C MarcusPhiline Wangemann
Feb 24, 2009·Trends in Neurosciences·Gary D HousleyAndreas Reichenbach
Apr 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gary D HousleyAllen F Ryan
Nov 6, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Srdjan M VlajkovicGary D Housley
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Sep 2, 2010·Purinergic Signalling·Narinobu Harada
Sep 2, 2010·Purinergic Signalling·Yan Zhu, Hong-Bo Zhao
Sep 2, 2010·Purinergic Signalling·Ken Ito, Didier Dulon
Sep 2, 2010·Purinergic Signalling·Lin-Chien HuangGary D Housley
Sep 2, 2010·Purinergic Signalling·Nicolas X TritschDwight E Bergles
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Nov 23, 2013·Journal of the Association for Research in Otolaryngology : JARO·Benjamin R Thiede, Jeffrey T Corwin
May 21, 2015·Purinergic Signalling·Geoffrey Burnstock, Nicholas Dale
Oct 12, 2020·Neuroscience Bulletin·Sasa Jovanovic, Ivan Milenkovic

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