PMID: 9191096Jun 1, 1997Paper

Localization of mRNA for fatty acid transport protein in developing and mature brain of rats

Brain Research. Molecular Brain Research
A UtsunomiyaH Kondo

Abstract

Gene expression for rat fatty acid transport protein (FATP) and fatty acid translocase (FAT) were examined by Northern and in situ hybridization analysis. In Northern blot analysis of developing brain, FATP mRNA was detected weakly throughout all developing stages without any changes in the expression level, while no gene expression for FAT mRNA was detected at any stages. By in situ hybridization histochemistry, intense expression was seen in the ventricular germinal zone on pre- and perinatal stages, whereas distinct expression was observed in the cerebellar Purkinje and granule cell during postpostnatal development. No expression was detected in the cerebellar external granule cell layer. Because of the high expression of FATP mRNA in the embryonic ventricular zone and the postnatal cerebellar cortical neurons in parallel to the gene expression for fatty acid binding protein (FABP) which we have recently reported, co-operated involvement of FATP and FABP in the active uptake of long-chain fatty acids is plausible in these cells.

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Citations

Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D F Horrobin
May 4, 1999·The International Journal of Biochemistry & Cell Biology·F A Van NieuwenhovenJ F Glatz
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Joseph R Marszalek, Harvey F Lodish
May 29, 2013·Lipids in Health and Disease·Jade GuestRoss Grant
Aug 6, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ryan W Mitchell, Grant M Hatch
Mar 1, 2012·Biomolecules & Therapeutics·Kazuhiro TanakaWei-Yi Ong
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Kemin QiRichard J Deckelbaum
Jan 8, 1999·Biochimica Et Biophysica Acta·B A FitscherW Stremmel

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