Localization of NADPH diaphorase in neurons of the rostral ventral medulla: possible role of nitric oxide in central autonomic regulation and oxygen chemoreception

Brain Research
C IadecolaX Xu

Abstract

We studied whether neurons containing nitric oxide synthase (NOS) are localized to the rostral ventrolateral medulla (RVM) and, if so, whether they are distinct from the adrenergic neurons of the C1 group. NOS-containing neurons and/or C1 neurons were visualized using NADPH diaphorase histochemistry and phenylethanolamine N-methyltransferase (PNMT) immunohistochemistry, respectively. A column of NADPH diaphorase-positive neurons, extending 2 mm in the rostrocaudal plane, was observed lateral to the inferior olive and medial to the C1 neurons. Double labelling studies showed that NADPH diaphorase-positive neurons were not immunoreactive for PNMT, indicating that the two enzymes were localized in the different cells. Furthermore, only a small fraction of NADPH diaphorase neurons were retrogradely labelled after injections of fluorogold into the thoracic cord. We conclude that the RVM contains a well-defined group of neurons endowed with NOS that are distinct from the adrenergic neurons of the C1 group and have only limited monosynaptic projections to the spinal cord. Since the RVM is involved in the control of arterial pressure and in oxygen-conserving reflexes, the findings raise the possibility that nitric oxide participates in...Continue Reading

References

Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Oct 28, 1991·Neuroscience Letters·L N ShapovalL S Pobegailo
Dec 22, 1985·The Journal of Comparative Neurology·C A RossD J Reis
Jan 1, 1989·The American Journal of Physiology·S HokaJ P Kampine
Jul 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A BerodJ F Pujol

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Citations

May 4, 1999·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·E E Benarroch, I L Smithson
Mar 31, 2012·Brain Structure & Function·Ruth L StornettaPatrice G Guyenet
Nov 1, 1994·Neuropharmacology·E M HullD S Lorrain
Mar 1, 1994·Neuroscience·N J DunU Förstermann
Jul 17, 1998·Brain Research·K MatsumuraM Fujishima
Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Feb 17, 1997·Journal of the Autonomic Nervous System·E E Benarroch, I L Smithson
Nov 22, 1996·Neuroscience Letters·B E KalischR J Boegman
Jan 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Takeshi IshideAhmmed Ally
Nov 14, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Vladimir A MaiskyHåkan Johansson
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·M Sander, R G Victor
Dec 22, 1999·The Japanese Journal of Physiology·M MaedaM Nakai
Aug 28, 2002·Anatomia, histologia, embryologia·M Nazu, T Thippeswamy
Nov 1, 1994·Baillière's Clinical Rheumatology·J A Goldstein
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaM E Ross

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