Localization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
A CardinaleMariarosa A B Melone

Abstract

Neuroglobin (Ngb) is expressed in the central and peripheral nervous system, cerebrospinal fluid, retina, and endocrine tissues where it is involved in binding O2 and other gasotransmitters. Several studies have highlighted its endogenous neuroprotective function. Huntington's disease (HD), a dominant hereditary disease, is characterized by the gradual loss of neurons in discrete areas of the central nervous system. We analyzed the expression of Ngb in the brain tissue of a mouse model of HD, in order to define the role of Ngb with respect to individual cell type vulnerability in HD and to gender and age of mice. Our results showed different expressions of Ngb among neurons of a specific region and between different brain regions. We evidenced a decreased intensity of Ngb at 13 weeks of age, compared to 7 weeks of age. The double immunofluorescence and fluorescence resonance energy transfer (FRET) experiments showed that the co-localization between Ngb and huntingtin at the subcellular level was not close enough to account for a direct interaction. We also observed a different expression of Ngb in the striatum, depending on the sex and age of animals. These findings provide the first experimental evidence for an adaptive respon...Continue Reading

References

Jan 1, 1995·Trends in Neurosciences·R L Albin, D A Tagle
Aug 3, 2000·Journal of Anatomy·J P BolamM D Bevan
Jul 10, 2003·Neuroscience Letters·Sylvia WystubStefan Reuss
Dec 8, 2004·Neurobiology of Aging·Yunjuan SunDavid A Greenberg
Feb 22, 2005·Current Drug Targets·Mariarosa A B MeloneGianfranco Peluso
Oct 19, 2007·Current Opinion in Pharmacology·David A GreenbergAdil A Khan
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adil A KhanDavid A Greenberg
Nov 24, 2007·Neuroscience Letters·Kunlin JinDavid A Greenberg
Apr 5, 2008·Nature Protocols·Andrew P FrenchTony P Pridmore
Apr 12, 2008·Stroke; a Journal of Cerebral Circulation·Xiaoying WangEng H Lo
Nov 18, 2008·Neurobiology of Aging·Megan SzymanskiDimitrios Avramopoulos
Dec 17, 2008·Annals of the New York Academy of Sciences·Susan E Browne
Jan 22, 2010·Apoptosis : an International Journal on Programmed Cell Death·Subhadip RaychaudhuriThomas Brittain
Jul 29, 2010·Physiological Reviews·Chiara ZuccatoElena Cattaneo
Apr 19, 2011·Handbook of Clinical Neurology·Jean Paul G VonsattelEtty Paola Cortes Ramirez
Dec 12, 2012·Neurobiology of Disease·Alessandro LeutiFrancesca R Fusco
May 8, 2013·Journal of Alzheimer's Disease : JAD·Fen SunKunlin Jin
Jan 1, 2012·Cells·Thomas Brittain
Jun 21, 2015·Expert Review of Neurotherapeutics·Cristina CarvalhoPaula I Moreira
Sep 18, 2016·Biochemical and Biophysical Research Communications·Rodrigo A QuintanillaMaría José Pérez
Nov 9, 2016·Molecular Aspects of Medicine·Paolo AscenziMaria Marino
Dec 14, 2016·Molecular Neurobiology·Maria Teresa NuzzoMaria Marino

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Citations

Jul 13, 2019·Neurotoxicity Research·Sachchida Nand RaiSurya Pratap Singh
Jul 12, 2018·Molecular Neurobiology·Zoë P Van AckerSylvia Dewilde
Feb 1, 2019·Metabolic Brain Disease·Rodrigo Rodrigues da ConceiçãoGisele Giannocco

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