Localization of neurotrophin-3-like immunoreactivity in the rat central nervous system

Brain Research
X F Zhou, R A Rush


Neurotropin-3 (NT3) is a nerve growth factor (NGF) homologue whose function is presently unknown. The factor promotes the survival of a subpopulation of sensory and sympathetic neurons in vitro. NT3 mRNA is widely distributed in both the peripheral and central nervous system but the distribution of NT3 has not yet been examined. In the present study we have determined the regional distribution and cellular localization of NT3-like immunoreactivity (-IR) in the central nervous system by immunohistochemistry. Both glia and neurons were stained. NT3-IR glia were distributed in corpus callosum, substantia nigra, fimbria of hippocampus, subependymal areas of the ventricles and cerebellum. In the forebrain, NT3-IR was detected in a number of neuronal cells, including pyramidal cells in the fifth layer of the cerebral cortices, subpopulations of neurons in the septal nuclei, diagonal bands of Broca, olfactory primary cortex, amygdala and islands of Calleja. In the hippocampus, pyramidal cells in the CA1, CA2 and lateral regions of CA3 and granular cells in dorsal dentate gyrus were labelled with different intensities. Neurons in the bed nuclei of the striatum terminalis, mesencephalic trigeminal nuclei and motoneurons in the brain ste...Continue Reading


Jul 1, 1992·Journal of Neuroscience Research·L A HuttonJ R Perez-Polo
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N Y IpS Squinto
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·U PirvolaM Saarma
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C KalcheimA Rosenthal
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Patrik ErnforsH Persson
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Jun 1, 1989·Neuron·Y A Barde
Feb 1, 1993·European Journal of Biochemistry·A Rodríguez-TébarA Arribas
Feb 1, 1993·Journal of Neuroscience Research·W HamelK Nikolics
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F Hory-LeeE Frank


Dec 22, 1999·The Journal of Comparative Neurology·C R BuckT C Cope
Apr 23, 1999·Journal of Neuroscience Research·Cheryl F DreyfusI B Black
Jul 12, 2002·Journal of Neuroscience Research·Yangzhou Du, Cheryl F Dreyfus
Mar 1, 1996·Progress in Neurobiology·Klaus Unsicker, K Krieglstein
Jun 26, 1998·Brain Research. Brain Research Reviews·B Connor, M Dragunow
Jun 6, 2000·Brain Research. Developmental Brain Research·M B HeatonD W Walker
Jun 6, 2003·Progress in Neurobiology·Volkmar LessmannMarzia Malcangio
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jun 5, 2004·Parkinsonism & Related Disorders·C KnottG P Wilkin
Dec 3, 1999·The European Journal of Neuroscience·F SedelA Triller
Jun 1, 1996·The European Journal of Neuroscience·K M Giehl, W Tetzlaff
Nov 20, 2004·PLoS Biology·Bariş GençReha S Erzurumlu
Jan 29, 2009·International Journal of Biological Sciences·V ZermeñoE Hernández-Echeagaray
Nov 29, 2015·Brain : a Journal of Neurology·Denise A DurickiLawrence D F Moon
Apr 1, 1999·Archives of Physiology and Biochemistry·I D NagtegaalE Marani
Jun 20, 2003·The Journal of Comparative Neurology·A J VigersK R Jones
May 11, 2010·Autonomic Neuroscience : Basic & Clinical·Luigi ManniL Aloe
Oct 5, 2007·Brain Research Reviews·Nikolai E Lazarov
Nov 19, 2003·The European Journal of Neuroscience·Oliver von Bohlen und HalbachKlaus Unsicker
Jul 18, 2009·Journal of Neuroscience Research·J FengD Kent Morest
Aug 11, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hong-Tian ZhangTim Ting-Hua Wang
May 30, 1998·Microscopy Research and Technique·A BuretteR Romand
Dec 22, 2017·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·W MaL-Y Li
Mar 30, 2004·Journal of Neuroscience Research·Hai WuCheryl F Dreyfus
Apr 9, 2005·Microscopy Research and Technique·Nadia ArcamonePaolo De Girolamo
Dec 22, 1999·The Journal of Comparative Neurology·A J VigersK R Jones

Related Concepts

Brain Stem
Structure of Interventricular Foramen
Corpus Callosum
Midbrain Structure
Neurite Outgrowth Factors

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.