PMID: 6986188Mar 3, 1980Paper

Localization of noradrenergic terminals in sympathetic preganglionic nuclei of the rat: demonstration by immunocytochemical localization of dopamine-beta-hydroxylase

Brain Research
E J Glazer, L L Ross

Abstract

The noradrenergic (NE) innervation to sympathetic preganglionic nuclei in the rat thoracic cord was studied by immunocytochemical localization of dopamine-beta-hydroxylase (DBH), a specific NE antigen. DBH antisera was prepared against DBH purified from bovine adrenal medulla. The most intense immunoreaction was observed within the intermediolateral cell column (IML) of the spinal cord, the major sympathetic preganglionic nucleus in mammals. DBH was also localized in both the central autonomic and intercalated nuclei, cell groups known to contain sympathetic preganglionic visceral motor neurons. Two weeks following a midthoracic spinal transection, DBH immunoreactivity was no longer observed caudal to the lesion. Thus, the cells of origin of these noradrenergic terminals are supraspinal. Following a midthoracic hemisection DBH, immunoreactivity was similarly reduced in both the ipsilateral and contralateral IML caudal to the lesion. Therefore, bulbospinal NE neurons project bilaterally to sympathetic preganglionic nuclei.

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Citations

May 1, 1990·Journal of Electron Microscopy Technique·B E MaleyR P Elde
Feb 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N FukuharaO Nakanishi
Nov 1, 1985·Journal of the Autonomic Nervous System·R A DampneyE Tan
Jan 1, 1988·Progress in Neurobiology·W Laskey, C Polosa
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·D N FranzC Sangdee
Jan 1, 1981·Clinical and Experimental Hypertension : CHE·J P ChalmersJ B Furness
Jan 10, 2006·Arquivos de neuro-psiquiatria·Manoel Baldoino Leal FilhoJosé Antonio Rocha Gontijo
Jun 12, 2002·International Journal of Impotence Research·E D YaïciF Giuliano
Jan 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shayne F AndrewSue Ritter
Jan 1, 1990·The European Journal of Neuroscience·K. FuxeM. Kalia
Dec 23, 1996·The Journal of Comparative Neurology·J C HolstegeC M Bongers
Oct 16, 2007·The Journal of Pain : Official Journal of the American Pain Society·Dennis C TurkNathan J Rudin

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