PMID: 11897808Mar 19, 2002Paper

Localization of NTPDase1/CD39 in normal and transformed human pancreas

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
A KittelGábor Varga

Abstract

Elevated levels of extracellular ATP have been observed in many tumors. We have localized NTPDase1/CD39, one of the principal extracellular nucleotide-hydrolyzing enzymes, in normal and cancerous human pancreas. NTPDase/E-ATPDase activity was demonstrated with an enzyme histochemical technique on cryosections of human pancreas. Acinar and duct epithelial cells were devoid of E-ATPDase activity in both normal and transformed tissue. Endothelial cells and smooth muscle around blood vessels and larger ducts showed strong activity. Nerves, connective tissue, and the beta-cells of the islets were also stained. In cancerous tissue this activity was diminished in the smooth muscle around the ducts and was absent from newly formed connective tissue. Immunostaining for CD39 supported these results but revealed the presence of inactive CD39 in the duct epithelial cells. We hypothesize that the significantly diminished activity of NTPDase1 in the tissues surrounding the ducts may be associated with the processes that lead to tumor formation in human pancreas.

References

Jul 1, 1992·British Journal of Pharmacology·D Hillaire-BuysM M Loubatières-Mariani
Jul 3, 1990·European Journal of Pharmacology·G BertrandM M Loubatières-Mariani
Aug 1, 1987·British Journal of Pharmacology·G BertrandM Roye
Sep 11, 1981·European Journal of Pharmacology·J Chapal, M M Loubatieres-Mariani
Oct 1, 1994·Trends in Neurosciences·H Zimmermann
Jan 1, 1994·Fundamental & Clinical Pharmacology·D Hillaire-BuysM M Loubatières-Mariani
May 15, 1993·Archives of Biochemistry and Biophysics·H B CunninghamA S Dahms
Jan 26, 1996·Biochemical and Biophysical Research Communications·K AyyanathanS P Kunapuli
Apr 26, 1996·The Journal of Biological Chemistry·T F Wang, G Guidotti
Dec 20, 1996·The Journal of Biological Chemistry·E KaczmarekS C Robson
Dec 1, 1996·Journal of Autonomic Pharmacology·H Zimmermann, N Braun
Feb 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A Kittel
Aug 24, 1999·The Journal of Physiology·H IshiguroM C Steward
Sep 2, 1999·Biochemical and Biophysical Research Communications·A KittelS C Robson
Jan 15, 2000·The Journal of Biological Chemistry·K KoziakS C Robson

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Citations

Jul 20, 2005·Histochemistry and Cell Biology·Agnes KittelBeáta Sperlágh
Mar 28, 2008·Purinergic Signalling·I Novak
Sep 6, 2003·Cancer Letters·Marcia R WinkAna M O Battastini
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·M Caroline Jacques-SilvaAlejandro Caicedo
Jun 24, 2004·Pancreas·Krisztina Sz KordásAgnes Kittel
Oct 15, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Magis MandapathilTheresa L Whiteside
May 8, 2007·Journal of Translational Medicine·Dianne PulteAaron J Marcus
Apr 18, 2009·Urologic Oncology·Joséli StellaAna Maria Oliveira Battastini
Jun 20, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Agnes KittelTerence L Kirley
Nov 16, 2013·Immunologic Research·Carmen FotinoAntonello Pileggi
May 9, 2006·The Journal of Comparative Neurology·Dianna L BartelThomas E Finger
Aug 4, 2006·The Journal of Biological Chemistry·Gennady G YegutkinIvana Novak
Jun 23, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Agnes KittelJean Sévigny
Aug 22, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Beat M KünzliSimon C Robson
Jan 10, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne WuttkeAnders Tengholm

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