Localization of osteonectin expression in human fetal skeletal tissues by in situ hybridization

Calcified Tissue International
M MetsärantaE Vuorio

Abstract

The expression of osteonectin gene was studied in developing human fetuses by Northern analysis and in situ hybridization. The highest levels of osteonectin mRNA were detected in RNA extracted from calvarial bones, growth plates, and skin. Low mRNA levels were present in several parenchymal tissues. In situ hybridization of developing long bones revealed three cell types with high osteonectin mRNA levels: osteoblasts, cells of the periosteum, and hypertrophic chondrocytes. Weaker signals were detected in osteocytes, fibroblasts of tendons, ligaments and skin, and in cells of the epidermis. Apart from the hypertrophic chondrocytes, only low osteonectin mRNA levels were seen in cartilage. The localization of osteonectin mRNA in fetal growth plates is consistent with the hypothesis that the protein plays a role in the mineralization of bone and cartilage matrices.

References

Jan 1, 1990·Connective Tissue Research·M F YoungJ D Termine
Jun 11, 1986·Nucleic Acids Research·M F YoungJ D Termine
Jan 11, 1988·Nucleic Acids Research·J K MäkeläE Vuorio
May 1, 1987·Cell and Tissue Research·G JundtA Schulz

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Citations

Jun 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·I M ClaussL H Glimcher
Oct 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P DominguezM F Young
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M GalottoR Cancedda
Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A L BronckersE H Burger
Jan 1, 1997·Archives of Orthopaedic and Trauma Surgery·P VirolainenH T Aro
Nov 1, 1996·Histochemistry and Cell Biology·E M AardenP J Nijweide
Dec 1, 1991·Calcified Tissue International·P BiancoP G Robey
Apr 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·M MetsärantaE Vuorio
Feb 3, 2009·Tissue Engineering. Part B, Reviews·Alexander C AlloriStephen M Warren
Apr 29, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S C DieudonnéM F Young
May 23, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jochen WeigeleReinhard Hilbig
Jul 14, 2007·Cells, Tissues, Organs·Kazuhiko KawasakiKenneth M Weiss
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J J Sauk
Jun 18, 2002·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Pierre J BouletreauMichael T Longaker
Jan 1, 1992·Kidney International·J B KoppP G Robey
Jan 1, 1994·Progress in Histochemistry and Cytochemistry·S Mundlos

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