Localization of precursor proteins and mRNA of type I and III collagens in usual interstitial pneumonia and sarcoidosis

Journal of Molecular Histology
R Kaarteenaho-WiikP Pääkkö

Abstract

The aim of this study was to assess and compare the accumulation and distribution of newly synthesized type I and III collagens in usual interstitial pneumonia (UIP) and pulmonary sarcoidosis. Lung biopsies from 10 patients with UIP and 13 patients with sarcoidosis were investigated by immunohistochemical technique and mRNA in situ hybridization. The antibodies for the aminoterminal propeptide of type I procollagen and the aminoterminal propeptide of type III procollagen (PINP and PIIINP, respectively) were used. When compared to healthy lung, levels of type I pN- and type III pN-collagens were increased in both of these disorders. Type I procollagen was mostly present as intracellular spots in newly formed fibrosis in UIP while type III pN-collagen was expressed extracellularly underneath metaplastic alveolar epithelium. Type I procollagen was present intracellularly within and around the granulomas of sarcoidosis, whereas type III pN-collagen was expressed extracellularly, mainly around the granulomas. mRNAs of both collagens colocalized with the precursor proteins. We conclude that the expression of precursor proteins and mRNA of type I and type III collagens is increased in UIP and sarcoidosis, reflecting mainly active synt...Continue Reading

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Citations

Dec 2, 2010·Respiratory Research·Terttu HarjuRiitta Kaarteenaho
Feb 6, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Riitta KaarteenahoPaavo Pääkkö
Feb 5, 2009·Ultrastructural Pathology·Riitta Kaarteenaho-WiikRaija Sormunen
Dec 25, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Gregorino PaoneClaudio Terzano
Mar 29, 2021·Pharmacology & Therapeutics·Gang LiuPhilip M Hansbro

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