PMID: 11919548Mar 29, 2002Paper

Localization of Reg receptor in rat fundic mucosa

The Journal of Laboratory and Clinical Medicine
Hideaki KazumoriYoshikazu Kinoshita

Abstract

Reg protein has a trophic effect on gastric mucosal cells and pancreatic islets. Recently, the Reg receptor (Reg-R) has been cloned, and Reg-Reg-R interaction has been reported in the pancreas. The aim of this study was to investigate the localization of Reg-R in rat fundic mucosa. Gene expression of Reg-R was investigated with Northern blot analysis, laser capture microdissection coupled with reverse transcription-polymerase chain reaction, and in situ hybridization in the fundic mucosa, and the types of cells expressing this gene were determined. Reg-R mRNA expression was detected mainly in chief cells and parietal cells of the deep layers and faintly in surface epithelial cells and mucous neck cells of the proliferating zone. Our results suggest that regenerating protein may act not only as a regulator of gastric epithelial cell proliferation but also as a modifier of other multiple physiologic functions.

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Citations

Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shunji IshiharaYoshikazu Kinoshita
Sep 27, 2005·The American Journal of Gastroenterology·Nagisa YoshinoYoshikazu Kinoshita
May 30, 2019·BioMed Research International·Xiangyun ZhuLing Li
Dec 12, 2003·World Journal of Gastroenterology : WJG·Yu-Wei ZhangMao-De Lai
Nov 22, 2015·Expert Opinion on Therapeutic Targets·Shin Takasawa
Nov 28, 2006·Nature Reviews. Cancer·Susan A WatsonArjun Takhar
May 15, 2012·Biomolecular Concepts·Abhirath ParikhEmmanuel S Tzanakakis
Dec 3, 2005·Virchows Archiv : an International Journal of Pathology·Kukka HeiskalaLeif C Andersson
Mar 20, 2008·World Journal of Gastroenterology : WJG·Reidar FossmarkHelge-L Waldum
Dec 20, 2005·The Journal of Surgical Research·Rolf GrafDaniel Bimmler

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