Localization of runx2, osterix, and osteopontin in tooth root formation in rat molars.

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Azumi HirataHiroaki Nakamura

Abstract

Cementogenesis starts with the differentiation of cementoblasts. Mature cementoblasts secrete cementum matrix. Cementum components are similar to bone; moreover, cementoblasts possess many characteristics similar to those of osteoblasts. Runx2 and osterix, the transcriptional factors for osteoblast differentiation, participate in tooth formation. However, the characteristics of Runx2 and osterix during the differentiation process of cementoblasts remain unclear. In this study, we examined the immunolocalization patterns of Runx2, osterix, and osteopontin during rat molar tooth formation. Periodontal ligament cells and osteoblasts located on the alveolar bone surface showed immunoreactivity for Runx2. Colocalization of Runx2 and osterix was detected in cementoblasts, which penetrated the ruptured Hertwig's epithelial root sheath and attached to root dentin. Moreover, osteopontin was observed in Runx2-positive cementoblasts facing the root surface. However, the cells adjacent to cementoblasts showed only Runx2 reactivity. Neither Runx2 nor osterix was seen in cementocytes. These results suggest that both Runx2 and osterix are important for differentiation into cementoblasts. Additionally, osterix may be indispensable for transcri...Continue Reading

References

Jun 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A L BronckersW T Butler
Apr 4, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D D Bosshardt, A Nanci
Jan 20, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F LézotA Berdal
Mar 7, 2001·Mechanisms of Development·A L BronckersR N D'Souza
Dec 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Thomas AbergRena N D'Souza
Apr 21, 2005·Journal of Dental Research·D D Bosshardt
Dec 27, 2005·Bone·Ieyoshi KobayashiHidetaka Sakai
Jan 19, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Janice E BerryLaurie K McCauley
Jun 20, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Azumi Hirata, Hiroaki Nakamura
Aug 23, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Akihiro HosoyaHidehiro Ozawa
Feb 22, 2007·Journal of Cellular Physiology·Dongwei FanYongfeng Shang
May 15, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Zenjiro MaruyamaToshihisa Komori
May 19, 2007·Biochemical and Biophysical Research Communications·Bruno Carmona-RodríguezHiginio Arzate
Jun 15, 2007·Journal of Biomedical Materials Research. Part a·Huihua FuJeffrey O Hollinger

❮ Previous
Next ❯

Citations

Nov 26, 2015·International Endodontic Journal·Y D HeL A Wu
Aug 11, 2015·Journal of Periodontal Research·S-J YuJ-C Park
Nov 2, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ioanna A TsiligkrouVassilios G Panis
Nov 10, 2012·Journal of Clinical Periodontology·Sandra Treves-ManusevitzSandu Pitaru
Jul 7, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Akihiro HosoyaHiroaki Nakamura
May 21, 2011·Cells, Tissues, Organs·Junsheng FengShuo Chen
Jul 12, 2017·Journal of Dental Research·X WangZ Cao
Dec 12, 2012·Journal of Cellular Biochemistry·Krishna M Sinha, Xin Zhou
Feb 6, 2010·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Birgit Rath-DeschnerWerner Götz
Apr 25, 2019·Minerva stomatologica·David A Trejo-RemigioJavier Portilla-Robertson
Aug 7, 2012·Journal of Bone and Mineral Metabolism·Ryosuke KagawaSatoru Toyosawa
Feb 9, 2019·Connective Tissue Research·Han-Wool ChoungJoo-Cheol Park
Jan 10, 2014·Journal of Diabetes and Metabolic Disorders·Subramaniam Sivakumar, Sivasitambaram Niranjali Devaraj
Jan 17, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Zhengguo CaoJian Q Feng
Aug 21, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chuan WangZhengguo Cao
Apr 19, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Phillip McClellanWilliam J Landis
Jan 24, 2020·International Journal of Molecular Sciences·Hiroaki TakebeKazuharu Irie
Apr 29, 2018·Journal of Periodontal Research·C WangZ Cao
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Shithima SayedByong-Taek Lee
Nov 12, 2016·Acta Biomaterialia·S R StockJ S Okasinski
Jun 3, 2021·International Journal of Molecular Sciences·Benedikt EggersMarjan Nokhbehsaim
Sep 8, 2021·Journal of Periodontal Research·Mengying LiHong He

❮ Previous
Next ❯

Methods Mentioned

BETA
Fluorescence

Software Mentioned

BZ Analyzer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.