PMID: 7536649Dec 1, 1994Paper

Localization of the complement membrane attack complex inhibitor (CD59) in human conjunctiva and lacrimal gland

Current Eye Research
D S BardensteinM E Medof

Abstract

Recent studies have established that complement is present in the eye and participates in ocular defense. The mechanisms by which ocular tissues are protected from bystander injury arising from local activation of the cascade, however, have not been characterized. Decay accelerating factor (DAF or CD55) and the membrane inhibitor of reactive lysis (MIRL or CD59) are cell surface regulatory proteins that protect blood cells from uptake of autologous C3b and polymerization of autologous C9 on their surfaces. In previous studies, we found that DAF is expressed in high levels on corneal, conjunctival, and lacrimal gland acinar surfaces. In this study we assayed ocular and lacrimal gland tissues for CD59. Immunohistochemical analyses demonstrated large amounts of the protein the same locations. The presence of CD59 in these sites is consistent with the proposal that CD59 functions together with DAF in protecting ocular tissues from autologous complement-mediated injury.

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Citations

Jan 31, 2013·International Reviews of Immunology·Michael E SternStephen C Pflugfelder
Jan 14, 1998·Current Eye Research·D S BardensteinM E Medof
Feb 27, 2008·Seminars in Immunopathology·Nalini S BoraPuran S Bora
Jan 9, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A EspositoM E Medof
Mar 23, 2001·Current Eye Research·E CocuzziE M Medof
Feb 24, 2001·Clinical and Experimental Immunology·E CocuzziM E Medof
Oct 13, 2000·Progress in Retinal and Eye Research·R A SackB Bogart

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