Localization of the effect of acetylcholine in regulating intestinal ion transport

The Journal of Physiology
J G BrowningJ S Redfern

Abstract

1. The location of the site involved in the secretory response of rat jejunum and colon to ACh was investigated by selectively damaging either the villi of the jejunum and the surface epithelium of the colon or the crypts. 2. The secretory response induced by ACh was measured both in terms of changes in electrical activity and chloride fluxes. 3. Exposure of the mucosa to 2 M-Na2SO4 for 30 min selectively damaged the jejunal villi and colonic surface epithelium but did not reduce the increased potential difference and current generated by ACh. 4. When resistance changes were taken into account the colonic response was markedly increased after Na2SO4 treatment although the jejunal response was unchanged. Under control conditions ACh reduced net Na absorption and stimulated Cl secretion by the colon. After exposure to Na2SO4 only the Cl secretory component of the ACh response remained, thus accounting for the enhanced effect. 5. Cycloheximide, administered I.V. at a dose of 12 mg/kg, damaged the crypts after 2 hr without affecting the villi of the jejunum or the surface epithelium of the colon. After cycloheximide treatment the increased potential difference, current and net Cl secretion induced by ACh were significantly reduced....Continue Reading

Citations

Feb 24, 1995·European Journal of Pharmacology·K E O'MalleyA W Baird
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J W RobinsonV Mirkovitch
Jan 1, 1988·Baillière's Clinical Gastroenterology·O Lundgren
Apr 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·T J Rimele, T S Gaginella
Jun 15, 1984·Klinische Wochenschrift·A Lückhoff, M Horster
Sep 19, 2006·British Journal of Pharmacology·C L Hirota, D M McKay
Sep 1, 1986·Veterinary Research Communications·L Ooms, A Degryse
Jan 20, 1999·Alimentary Pharmacology & Therapeutics·B Greenwood-Van MeerveldN Ogata
Aug 27, 2004·Acta Physiologica Scandinavica·R LarsenA Mertz-Nielsen
Jul 1, 1982·Pflügers Archiv : European journal of physiology·S Gazitúa, J W Robinson
Dec 1, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C J Edmonds
Nov 28, 2008·American Journal of Physiology. Cell Physiology·Nirish ShahJean-Pierre Raufman
Feb 1, 1986·The Journal of Pharmacy and Pharmacology·R WahawisanT S Gaginella
Aug 8, 1998·The American Journal of Physiology·J P RaufmanA Bartoszko-Malik
Oct 1, 2011·American Journal of Physiology. Cell Physiology·Hatim A HassanPeter S Aronson
Oct 1, 1986·The American Journal of Physiology·C J Venglarik, D C Dawson
Aug 17, 1983·Biochimica Et Biophysica Acta·P T BeallL L Shanbour

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