Localization of the Epileptogenic Zone Using High Frequency Oscillations

Frontiers in Neurology
Aljoscha ThomschewskiBirgit Frauscher

Abstract

For patients with drug-resistant focal epilepsy, surgery is the therapy of choice in order to achieve seizure freedom. Epilepsy surgery foremost requires the identification of the epileptogenic zone (EZ), defined as the brain area indispensable for seizure generation. The current gold standard for identification of the EZ is the seizure-onset zone (SOZ). The fact, however that surgical outcomes are unfavorable in 40-50% of well-selected patients, suggests that the SOZ is a suboptimal biomarker of the EZ, and that new biomarkers resulting in better postsurgical outcomes are needed. Research of recent years suggested that high-frequency oscillations (HFOs) are a promising biomarker of the EZ, with a potential to improve surgical success in patients with drug-resistant epilepsy without the need to record seizures. Nonetheless, in order to establish HFOs as a clinical biomarker, the following issues need to be addressed. First, evidence on HFOs as a clinically relevant biomarker stems predominantly from retrospective assessments with visual marking, leading to problems of reproducibility and reliability. Prospective assessments of the use of HFOs for surgery planning using automatic detection of HFOs are needed in order to determin...Continue Reading

References

Jan 1, 1991·Brain Topography·S J WilliamsonL Kaufman
Dec 1, 1994·Electroencephalography and Clinical Neurophysiology·G CurioW Härer
Sep 1, 1997·IEEE Transactions on Bio-medical Engineering·B D Van VeenA Suzuki
Jan 1, 1999·Electroencephalography and Clinical Neurophysiology·I OzakiI Hashimoto
May 5, 1999·Hippocampus·A BraginG Buzsáki
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J GrossR Salmelin
Aug 28, 2001·Brain : a Journal of Neurology·F Rosenow, H Lüders
Feb 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anton SirotaGyörgy Buzsáki
Feb 14, 2004·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·N V Reva, L I Aftanas
Apr 23, 2004·Epilepsia·Katsuhiro KobayashiEiji Oka
Jun 25, 2004·Brain : a Journal of Neurology·Anne M McIntoshSamuel F Berkovic
Jul 6, 2004·Annals of Neurology·Richard J StabaJerome Engel
Sep 21, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·P Kwan, J W Sander
Jun 28, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Avgis HadjipapasGareth R Barnes
Oct 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tomoyuki AkiyamaO Carter Snead
Nov 22, 2005·Clinical EEG and Neuroscience·Isamu Ozaki, Isao Hashimoto
Apr 25, 2006·Brain : a Journal of Neurology·J D JirschJ Gotman
Sep 1, 2006·IEEE Transactions on Bio-medical Engineering·Esen Küçükaltun-YildirimRichard M Leahy
Mar 27, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrew B GardnerBrian Litt
Jul 7, 2007·Brain : a Journal of Neurology·Zsófia ClemensJan Born
Jul 13, 2007·Brain : a Journal of Neurology·Elena UrrestarazuJean Gotman
Feb 22, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hiroshi OtsuboElizabeth J Donner
May 10, 2008·Neuron·Shlomit Yuval-GreenbergLeon Y Deouell
May 27, 2008·Brain : a Journal of Neurology·Nikolai AxmacherJuergen Fell
Apr 21, 2009·Epilepsy Research·Katsuhiro KobayashiYoko Ohtsuka
May 29, 2009·Epileptic Disorders : International Epilepsy Journal with Videotape·Jing XiangDouglas Rose
Sep 12, 2009·Brain : a Journal of Neurology·Catherine A SchevonR G Emerson
Dec 4, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C G BénarF Wendling
Jan 2, 2010·Journal of Neurosurgery. Pediatrics·Jing XiangTon DeGrauw
Feb 18, 2010·Current Opinion in Neurology·Anatol BraginRichard J Staba
May 18, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Naotaka UsuiYushi Inoue
May 19, 2010·Epilepsia·Stefan RamppHermann Stefan

❮ Previous
Next ❯

Citations

Mar 28, 2020·Journal of Neural Engineering·Carolina MigliorelliVictoria San Antonio-Arce
Feb 13, 2020·Current Opinion in Neurology·Birgit Frauscher
Oct 21, 2020·Nature Reviews. Neurology·Rima Nabbout, Mathieu Kuchenbuch
Oct 20, 2020·Frontiers in Neurology·Sriharsha RamarajuPeter N Taylor
Oct 22, 2020·Epilepsy Currents·Julia Jacobs, Maeike Zijlmans
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tamir AvigdorBirgit Frauscher
Sep 11, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniMark Hallett
Mar 13, 2021·Annals of Neurology·Eleonora TamiliaChristos Papadelis
Apr 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Zhengxiang CaiBin He
May 5, 2021·CNS Neuroscience & Therapeutics·Li-Juan ShiJi-Cong Zhang
May 12, 2021·Seizure : the Journal of the British Epilepsy Association·Jing XiangJeffrey Tenney
Nov 21, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Syu-Jyun PengChi-Long Chen
Jul 13, 2021·Frontiers in Neurology·Yasushi IimuraHiroshi Otsubo
Sep 25, 2021·Scientific Data·Martin G FraschReinhard Bauer

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Software Mentioned

wMEM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.