PMID: 7027261Jul 1, 1981Paper

Localization of the human insulin gene to the distal end of the short arm of chromosome 11

Proceedings of the National Academy of Sciences of the United States of America
M E HarperG F Saunders

Abstract

The human insulin gene was mapped by hybridization in situ of 3H-labeled recombinant plasmid pHIG900 to chromosome preparations in the presence of 10% dextran sulfate. pHIG900 contains a 900-base pair insert of human genomic DNA that includes the coding region for the C peptide and intervening sequence 2. A significant percentage of hybridized cells (34%) exhibited silver grains on the distal end of the short arm (band p15) of chromosome 11. Furthermore, silver grains on this region represented 26% of all chromosomal label. These results demonstrate chromosomal localization of the human insulin gene to 11p15.

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Jan 1, 1993·Diagnostic Cytopathology·F H Sarkar, D W Visscher
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