Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex

Neuroscience
Marcello MeloneFiorenzo Conti

Abstract

We studied the distribution and cellular localization of Na(+)-coupled neutral amino acid transporter 2, a member of the system A family of amino acid transporters, in the rat and human cerebral cortex using immunocytochemical methods. Na(+)-coupled neutral amino acid transporter 2-positive neurons were pyramidal and non-pyramidal, and Na(+)-coupled neutral amino acid transporter 2/GABA double-labeling studies revealed that Na(+)-coupled neutral amino acid transporter 2 was highly expressed by GABAergic neurons. Double-labeling studies with the synaptophysin indicated that rare axon terminals express Na(+)-coupled neutral amino acid transporter 2. Na(+)-coupled neutral amino acid transporter 2-immunoreactivity was also found in astrocytes, leptomeninges, ependymal cells and choroid plexus. Electron microscopy showed robust Na(+)-coupled neutral amino acid transporter 2-immunoreactivity in the somato-dendritic compartment of neurons and in glial processes, but, as in the case of double-labeling studies, failed to reveal Na(+)-coupled neutral amino acid transporter 2-immunoreactivity in terminals. To rule out the possibility that the absence of Na(+)-coupled neutral amino acid transporter 1- and Na(+)-coupled neutral amino acid t...Continue Reading

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Citations

Apr 28, 2006·Neuroreport·Tomaso VecchiPietro Pietrini
Mar 3, 2012·Neurochemistry International·Paul DesjardinsRoger F Butterworth
Jul 2, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Angelina RodríguezGarcía-Alcocer María Guadalupe
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Feb 5, 2015·Journal of Neuroscience Research·Mari-Carmen MarxBrian Billups
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Jul 4, 2019·Scientific Reports·Erik FasteriusCristina Al-Khalili Szigyarto
Jul 25, 2021·International Journal of Molecular Sciences·Mark W SherwoodAude Panatier

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