PMID: 11335129May 4, 2001Paper

Localization of the netrin guidance receptor, DCC, in the developing peripheral and enteric nervous systems

Mechanisms of Development
C SeamanHelen M Cooper

Abstract

Over recent years the secreted guidance cue, netrin-1, and its receptor, DCC, have been shown to be an essential guidance system driving axon pathfinding within the developing vertebrate central nervous system (CNS). Mice lacking DCC exhibit severe defects in commissural axon extension towards the floor plate demonstrating that the DCC-netrin guidance system is largely responsible for directing axonal projections toward the ventral midline in the developing spinal cord (Fazeli et al., Nature 386 (1997) 796). In addition, these mutants lack several major commissures within the forebrain, including the corpus callosum and the hippocampal commissure. In contrast to the CNS, the role of the DCC guidance receptor in the development of the mammalian peripheral and enteric nervous systems (PNS and ENS) has not been investigated. Here we demonstrate using immunohistochemical analysis that the DCC receptor is present in the developing mouse PNS where it is found on spinal, segmental, and sciatic nerves, and in developing sensory ganglia and their associated axonal projections. In addition, DCC is present in the ENS throughout the early developmental phase.

Citations

Dec 11, 2003·Molecular and Cellular Neurosciences·Sonia Montazeri, Thomas Skutella
Sep 12, 2006·Nature Neuroscience·Karen Y WuSamie R Jaffrey
Apr 28, 2006·Journal of Pediatric Gastroenterology and Nutrition·Jaime Belkind-GersonHarland Winter
Aug 28, 2012·Trends in Molecular Medicine·Suh Youn KoKulmira Nurgali
Jul 20, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cornelia Fricke, Chi-Bin Chien
Aug 21, 2007·The Journal of Comparative Neurology·David M HowellPeter H Mathers
Aug 20, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E M RatcliffeE A Fox
Jun 18, 2005·Brain Research. Brain Research Reviews·María J BarallobreEduardo Soriano
Jul 6, 2004·Autonomic Neuroscience : Basic & Clinical·H M YoungC R Anderson
Oct 25, 2016·Biological Psychiatry·Angélica Torres-BerríoCecilia Flores
Apr 5, 2016·Scientific Reports·Young J KimLi I Zhang
Jul 21, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Marco MetzgerLothar Just
Mar 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daniel P FitzgeraldHelen M Cooper
Dec 24, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Suh Youn KoKulmira Nurgali

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