Localization of the neurally mediated arrhythmogenic properties of digitalis

Science
J C Somberg, T W Smith

Abstract

Available evidence suggests that the propensity of digitalis glycosides to produce cardiac arrhythmias is due in part to their neuroexictatory effects. We have performed experiments in cats which support the existence of a neurogenic component in the etiology of digitalis-induced ventricular arrhythmias. Our data further indicate that the locus of this neural effect lies within an area of the medulla 2 millimeters above to 2 millimeters below the obex. These findings, when considered with the effects of polar cardiac glycosides that do not cross the blood-brain barrier, suggest that the area postrema may be the site of neural activation.

References

May 1, 1976·European Journal of Pharmacology·H M RheeB H Marks
Dec 1, 1978·Circulation Research·G H MudgeT W Smith
Apr 1, 1975·European Journal of Pharmacology·P R Saxena, K P Bhargava
Nov 1, 1975·Circulation·R A Gillis
Jun 1, 1976·The American Journal of Cardiology·B LevittR Gillis
Dec 1, 1974·The Journal of Clinical Investigation·H GaranW J Powell
Nov 1, 1973·The New England Journal of Medicine·T W Smith, E Haber
Jun 1, 1972·British Journal of Pharmacology·B N Basu RayS N Pradhan
Feb 1, 1961·The Journal of Comparative Neurology·E TABER

❮ Previous
Next ❯

Citations

Sep 1, 1987·Electroencephalography and Clinical Neurophysiology·C M LathersF L Weiner
Nov 21, 1980·European Journal of Pharmacology·S P SivamS C Manchanda
Dec 3, 1982·European Journal of Pharmacology·J T Fleming, J E Holl
Apr 8, 1982·European Journal of Pharmacology·K Kujime, B H Natelson
Nov 10, 1980·Life Sciences·C M Lathers, J Roberts
May 1, 1985·Journal of the American College of Cardiology·J C Longhurst, J Ross
Apr 17, 2001·American Journal of Therapeutics·J C Somberg
Jan 1, 1988·Reviews in Clinical & Basic Pharmacology·C M LathersH Klions
Apr 1, 1984·Pediatric Cardiology·A R HastreiterE Chow-Tung
Jan 1, 1981·Pharmacology & Therapeutics·R S Kim, F S LaBella
Aug 1, 1981·Clinical Toxicology·P SedgwickR H Cravey
Jan 1, 1993·Journal of Toxicology. Clinical Toxicology·P TabouletC Bismuth
May 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Mar 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Sep 1, 1982·American Heart Journal·K OtsukaT Yanaga
Sep 1, 1992·Journal of Clinical Anesthesia·P M Heerdt, M E Heerdt
Jan 1, 1985·The Anatomical Record·H H TraurigN H Bass
Jan 1, 1987·The Journal of Pharmacy and Pharmacology·L M Plunkett, R L Tackett
Oct 1, 1985·Journal of Clinical Pharmacology·C M LathersH A Klions
Dec 31, 1997·Medizinische Klinik·T A Fischer, N Treese
Jul 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.