Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma

International Journal of Cancer. Journal International Du Cancer
Mads Nikolaj Holten-AndersenBoye Schnack Nielsen

Abstract

Tissue inhibitor of matrix metalloproteases 1 (TIMP-1) inhibits the proteolytic activity of matrix metalloproteases and hereby prevents cancer invasion. However, TIMP-1 also possesses other functions such as inhibition of apoptosis, induction of malignant transformation and stimulation of cell-growth. We have previously demonstrated that TIMP-1 is elevated in blood from colorectal cancer patients and that high TIMP-1 levels predict poor prognosis. To clarify the role of TIMP-1 in colorectal tumorigenesis, the expression pattern of TIMP-1 in benign and malignant colorectal tumors was studied. In all of 24 cases of colorectal adenocarcinoma TIMP-1 mRNA was detected by in situ hybridization. In all cases TIMP-1 expression was found in fibroblast-like cells located at the invasive front but was seen only sporadically in normal mucosa. No TIMP-1 mRNA was seen in any of the cases in benign or malignant epithelial cells, in vascular cells or smooth muscle cells. Comparison of sections processed for TIMP-1 in situ hybridization with sections immunohistochemically stained with antibodies against TIMP-1 showed good correlation between TIMP-1 mRNA and immunoreactivity. Combining TIMP-1 in situ hybridization with immunohistochemical staini...Continue Reading

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Citations

Nov 12, 2010·Clinical & Experimental Metastasis·Boye Schnack NielsenHans Jørgen Nielsen
Jan 10, 2013·The Journal of Clinical Investigation·Yosuke OsawaOsamu Kozawa
Nov 19, 2013·Apoptosis : an International Journal on Programmed Cell Death·Pu XiaYang Bai
Mar 7, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Irene Vejgaard SorensenPernille A Usher
Jun 28, 2008·Scandinavian Journal of Gastroenterology·Nanna Møller SørensenNils Brünner
Sep 1, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·C FrederiksenH J Nielsen
Aug 19, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bastian SeubertAchim Krüger
Jul 14, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Helgi BirgissonNils Brünner
Dec 30, 2009·Journal of Surgical Oncology·Michel F P van der JagtPaul N Span
Sep 16, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Antonio Z Gimeno-GarcíaEnrique Quintero
Oct 25, 2016·Journal of Cellular Physiology·Sara CrottiMarco Agostini
Jul 3, 2016·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Warner Alpízar-AlpízarMartin Illemann
Oct 11, 2008·The American Journal of Gastroenterology·Ole D LaerumBoye S Nielsen
Sep 23, 2020·The Journal of International Medical Research·Jun LiuJie-An Huang
May 12, 2009·Journal of Neuro-oncology·Charlotte Aaberg-JessenBjarne Winther Kristensen
May 12, 2006·Molecular Cancer Research : MCR·Martin IllemannBoye Schnack Nielsen

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