Localized characterization of brain tissue mechanical properties by needle induced cavitation rheology and volume controlled cavity expansion.

Journal of the Mechanical Behavior of Biomedical Materials
Aleksandar S MijailovicKrystyn J Van Vliet

Abstract

Changes in the elastic properties of brain tissue have been correlated with injury, cancers, and neurodegenerative diseases. However, discrepancies in the reported elastic moduli of brain tissue are persistent, and spatial inhomogeneities complicate the interpretation of macroscale measurements such as rheology. Here we introduce needle induced cavitation rheology (NICR) and volume-controlled cavity expansion (VCCE) as facile methods to measure the apparent Young's modulus E of minimally manipulated brain tissue, at specific tissue locations and with sub-millimeter spatial resolution. For different porcine brain regions and sections analyzed by NICR, we found E to be 3.7 ± 0.7 kPa and 4.8 ± 1.0 kPa for gray matter, and white matter, respectively. For different porcine brain regions and sections analyzed by VCCE, we found E was 0.76 ± 0.02 kPa for gray matter and 0.92 ± 0.01 kPa for white matter. Measurements from VCCE were more similar to those obtained from macroscale shear rheology (0.75 ± 0.06 kPa) and from instrumented microindentation of white matter (0.97 ± 0.40 kPa) and gray matter (0.86 ± 0.20 kPa). We attributed the higher stiffness reported from NICR to that method's assumption of a cavitation instability due to a neo...Continue Reading

References

Aug 15, 2000·Journal of Biomechanics·K MillerP Bednarz
Apr 6, 2002·Journal of Biomechanics·Karol Miller, Kiyoyuki Chinzei
May 11, 2002·Journal of Biomechanical Engineering·Michael T Prange, Susan S Margulies
Jul 28, 2004·Journal of Biomechanics·Amit Gefen, Susan S Margulies
Nov 30, 2005·Biomechanics and Modeling in Mechanobiology·F VelardiM Angelillo
Dec 27, 2005·Journal of Biomechanics·Shaokoon Cheng, Lynne E Bilston
May 7, 2008·NMR in Biomedicine·Michael A GreenRalph Sinkus
Jun 6, 2008·Journal of Biomechanical Engineering·M HrapkoJ S H M Wismans
Jul 11, 2008·Medical Engineering & Physics·Shaokoon ChengLynne E Bilston
Aug 25, 2009·Journal of Biomechanics·Mehdi ShafieianJames R Stone
Feb 5, 2010·Journal of the Mechanical Behavior of Biomedical Materials·J A W van DommelenG W M Peters
Jul 7, 2010·Acta Biomaterialia·Thibault P PrevostSimona Socrate
Feb 19, 2011·Journal of Biomechanics·T KasterA Samani
Jul 14, 2011·Journal of Magnetic Resonance Imaging : JMRI·Matthew C MurphyRichard L Ehman
Aug 10, 2011·Journal of Biomechanical Engineering·Benjamin S ElkinBarclay Morrison
Aug 30, 2011·Journal of Neuroscience Methods·Thomas BouletShadi F Othman
Apr 24, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Badar RashidMichael D Gilchrist
Jun 1, 2012·Stem Cells and Development·Anna JagielskaRobin J M Franklin
Nov 21, 2012·Nature Reviews. Neuroscience·William J Tyler
Jan 30, 2013·Plastic and Reconstructive Surgery·Michael S ChinAlfred J Crosby
May 7, 2013·Annual Review of Biomedical Engineering·Kristian FranzeJochen Guck
Sep 13, 2013·Journal of Biomechanical Engineering·Benjamin S Elkin, Barclay Morrison
Sep 17, 2013·Journal of Neurosurgery·Abdulghader M AlfasiMarc R Del Bigio
Oct 9, 2013·Journal of the Mechanical Behavior of Biomedical Materials·S J LeeM Sarntinoranont
Apr 2, 2014·Soft Matter·Shelby B Hutchens, Alfred J Crosby
Mar 31, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Silvia BuddayEllen Kuhl
Apr 7, 2015·New Journal of Physics·Katarzyna PogodaPaul A Janmey
Jul 21, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Lauren E JansenShelly R Peyton
Sep 12, 2015·Journal of the Royal Society, Interface·L Angela MihaiAlain Goriely
Feb 4, 2016·Soft Matter·Shelby B HutchensAlfred J Crosby
Sep 30, 2016·Journal of Visualized Experiments : JoVE·Elizabeth Peruski CanovicKrystyn J Van Vliet
Jun 29, 2017·Acta Biomaterialia·S BuddayE Kuhl
Oct 18, 2018·PloS One·Samuel R PolioShelly R Peyton
Feb 1, 2019·Scientific Reports·Mateusz M UrbanskiCarmen V Melendez-Vasquez
May 11, 2019·Soft Matter·Shabnam Raayai-ArdakaniTal Cohen
May 23, 2007·Soft Matter·Jessica A ZimberlinAlfred J Crosby

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.