Localized cutaneous leishmaniasis (chiclero's ulcer) in Mexico: sensitivity and specificity of ELISA for IgG antibodies to Leishmania mexicana mexicana

Transactions of the Royal Society of Tropical Medicine and Hygiene
M R Garcia-MissA L Cruz-Ruiz

Abstract

Sera from 223 human beings were assayed by enzyme-linked immunosorbent assay for immunoglobulin G antibodies to Leishmania mexicana mexicana promastigotes. 76% of 74 sera from patients with chiclero's ulcer gave positive reactions at a titre of 1:40; the positivity rate was lower in patients with long-standing infections. False positive reactions were obtained with only 7% of 56 sera from healthy individuals with positive Montenegro tests and with 6 of 7 sera from patients with Chagas disease. It is concluded that this method would be a useful contributory diagnostic method in cases of suspected chiclero's ulcer.

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Citations

Jun 29, 1999·Clinics in Dermatology·O Y Oumeish
Apr 4, 2001·Memórias do Instituto Oswaldo Cruz·F J Andrade-NarváezA G Damián-Centeno
Jan 1, 1997·Memórias do Instituto Oswaldo Cruz·A Monroy-OstriaL Favila-Castillo
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Jul 1, 1993·Clinical Microbiology Reviews·G Grimaldi, R B Tesh

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