Localized delivery of methylprednisolone sodium succinate with polymeric nanoparticles in experimental injured spinal cord model

Pharmaceutical Development and Technology
Yasemin Karabey-AkyurekLevent Oner

Abstract

With important social and economic consequences, spinal cord injuries (SCIs) still exist among major health problems. Although many therapeutic agents and methods investigated for the treatment of acute SCI, only high dose methylprednisolone (MP) is being used currently in practice. Due to the serious side effects, high dose systemic MP administration after SCI is a critical issue that is mostly considered controversial. In our study, it is aimed to develop a nanoparticle-gel combined drug delivery system for localization of MP on trauma site and eliminating dose-dependent side effects by lowering the administered dose. For this purpose, methyl prednisolone sodium succinate (MPSS) loaded polycaprolactone based nanoparticles were developed and embedded in an implantable fibrin gel. The effects of MPSS delivery system are evaluated on an acute SCI rat model, by quantification the levels of three inflammatory cytokines (interleukin-1β, interleukin-6 and caspase-3) and assessment of the damage on ultrastructural level by transmission electron microscopy. Developed NP-gel system showed very similar results with systemic high dose of MPSS. It is believed that developed system may be used as a tool for the safe and effective localized...Continue Reading

References

Feb 1, 1991·The Journal of Surgical Research·H B KramW C Shoemaker
Oct 25, 1990·The New England Journal of Medicine·R S Bockman
Jan 1, 1990·Journal of Neurotrauma·W Young
Oct 1, 1993·Annals of Surgery·S GalandiukH C Polk
Jun 1, 1993·Annals of Emergency Medicine·F H GeislerW P Coleman
Jan 20, 1997·The Journal of Comparative Neurology·P G PopovichB T Stokes
Feb 1, 1997·The Journal of Trauma·S J GerndtS M Papadopoulos
Dec 5, 1998·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·P MaroneE Antoniazzi
Apr 9, 1999·Drug Development and Industrial Pharmacy·J M BarichelloT Nagai
Jul 30, 1999·Nature Medicine·J E SpringerP E Knapp
Apr 13, 2000·Spinal Cord·V PointillartP Dabadie
Dec 6, 2000·Progress in Brain Research·J R Bethea
Aug 28, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H HugenholtzC Short
Jul 13, 2004·The Spine Journal : Official Journal of the North American Spine Society·Brian K KwonAlexander R Vaccaro
Jul 21, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara J TaylorShelly E Sakiyama-Elbert
Apr 19, 2006·Journal of Neuroscience Research·Peishan Liu-SnyderRiyi Shi
Nov 23, 2006·Journal of Biomedical Materials Research. Part a·Suk Ho BhangByung-Soo Kim
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Catarina Pinto ReisFrancisco Veiga
Jul 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yong-Il ChungGiyoong Tae
Dec 7, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Omer Faruk TurkogluEtem Beskonakli
Jan 13, 2009·International Journal of Pharmaceutics·Erem BilensoyN Aydin Mungan
Feb 3, 2009·Biomaterials·Young-tae KimRavi V Bellamkonda
Apr 14, 2009·Cellular and Molecular Neurobiology·Peter GálDarina Kluchová
Oct 13, 2009·World Journal of Surgery·William D Spotnitz
Jan 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bart J CrielaardGert Storm
Jun 27, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pieter J GaillardArie Reijerkerk
Oct 27, 2012·Handbook of Clinical Neurology·Daniel Becker, John W McDonald

❮ Previous
Next ❯

Citations

Jan 5, 2020·Molecular Neurobiology·Tasneem Ismail KhanMohammad Waseem
Apr 17, 2020·European Journal of Hospital Pharmacy. Science and Practice·Chen Peng, Jie-Xin Lei
Aug 11, 2020·Journal of Biological Engineering·Ziyuan YuZhiping Qi
Aug 30, 2020·Neural Regeneration Research·Robert B Shultz, Yinghui Zhong
Jul 23, 2020·Advanced Drug Delivery Reviews·Romain BrusiniPatrick Couvreur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.