PMID: 9159163May 27, 1997Paper

Localized gene action controlling intestinal neoplasia in mice

Proceedings of the National Academy of Sciences of the United States of America
K A Gould, W F Dove

Abstract

Mice heterozygous for the ApcMin (Min) mutation develop adenomas throughout the intestinal tract. Apc is believed to be involved in cell migration, adhesion, and polarity. Adenoma multiplicity and growth rate are modulated by an unlinked modifier locus, Mom1. The secretory phospholipase Pla2g2a is a candidate for Mom1. Here, we investigate the range of action of Apc and Mom1. Analysis of chimeric Min mice indicates that the actions of both Apc and Mom1 are localized within the cell lineage that gives rise to intestinal tumors.

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Citations

May 7, 2011·Molecular Genetics and Genomics : MGG·Jean-Louis Guénet
Jan 23, 1999·Current Opinion in Cell Biology·T S StappenbeckJ I Gordon
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrew T ThliverisRichard B Halberg
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C HagiosM J Bissell
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W F DoveA R Shoemaker
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M R NovelliW F Bodmer
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Emmelie A JanssonSven Pettersson
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·A J MerrittW F Dove
Jul 11, 1998·Experimental Lung Research·K A Gould, W F Dove
Sep 24, 1999·Developmental Biology·W C KisseberthE P Sandgren
Aug 19, 2003·Nature Genetics·William Dove
May 10, 2000·The Journal of Biological Chemistry·G Ghiselli, R V Iozzo

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