Localized gene transfer and its application for the study of central cardiovascular control

Autonomic Neuroscience : Basic & Clinical
Y Hirooka

Abstract

The arterial baroreceptor reflex is the major feedback control system that acts to stabilize blood pressure. Abnormalities of this reflex are considered to be an underlying mechanism in the cardiovascular diseases such as hypertension and heart failure. There is accumulating evidence, however, that central nervous system mechanisms are involved in the enhanced sympathetic drive that occurs in these disease states. This article reviews studies performed in our laboratory in which a gene transfer technique, in combination with other methods, was used to determine the functional role of the central control of cardiovascular regulation. We developed a technique to transfer adenovirus vectors encoding specific genes into the nucleus tractus solitarii (NTS) or the rostral ventral medulla (RVLM) of rats in vivo. We applied this technique to hypertensive rats as well as in mice with heart failure to explore the pathophysiological significance of nitric oxide, reactive oxygen species, and Rho-kinase.

References

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Dec 18, 2004·Drug News & Perspectives·Yoshitaka HirookaAkira Takeshita
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Citations

Jun 3, 2009·Current Heart Failure Reports·Harold D Schultz
Jul 25, 2008·Autonomic Neuroscience : Basic & Clinical·Yoshitaka Hirooka
Mar 22, 2007·Respiratory Physiology & Neurobiology·Harold D Schultz, Yu Long Li
Feb 4, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshitaka HirookaKenji Sunagawa
Jun 27, 2020·Nitric Oxide : Biology and Chemistry·Ahmmed AllySurya M Nauli

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