Localized grade I non-Hodgkin's lymphoma: results of treatment with radiotherapy alone in 88 patients

Clinical Oncology : a Journal of the Royal College of Radiologists
N A SpryA Jelliffe

Abstract

Eighty-eight patients entered into the British National Lymphoma Investigation with clinical stage I and II, grade I non-Hodgkin's lymphoma were treated initially with involved field radiotherapy alone. Eighty-one per cent presented with nodal disease. The duration of follow-up was 25-116 months, with a median of 54 months. Fifteen patients died of disease and the 5-year survival of the whole group was 83%. The complete response rate was dependent on the radiotherapy dose and was greater than 90% for doses of 3500 cGy and over. Most failures occurred at distant rather than adjacent sites, suggesting that extended field radiotherapy would not have affected the outcome. Second-line treatment induced complete remission in 66% of patients who relapsed. The prognosis was significantly worse in patients with intra-abdominal disease.

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Citations

Jul 6, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael MacManusJohn F Seymour
Mar 7, 2009·Hematological Oncology·R L M Haas

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