Localized infantile hemangiomas of the face and scalp: Predilection for the midline and periorbital and perioral skin

Pediatric Dermatology
Anita N HaggstromIlona J Frieden

Abstract

Infantile hemangiomas are common vascular tumors. Identifying sites of predilection may provide insight into pathogenesis. Previous studies have suggested a predilection for the boundary of facial metameres. The objective was to observe patterns of localized hemangiomas on the face and scalp, determine sites of predilection, and place these patterns in a developmental context. A retrospective review of photographic archives at 10 Hemangioma Investigator Group pediatric dermatology centers identified localized infantile hemangiomas of the face and scalp. Heat map software was used to identify areas of predilection. Dot maps were used to assess frequency, and densities of infantile hemangiomas were compared between facial units using t-testing. The scalp was divided into quintiles to assess relative frequencies. Four thousand one hundred fifty-three focal face and scalp infantile hemangiomas were mapped, of which 2962 (71%) were mapped to a frontal facial template. On the face, 73.8% (2186/2962) of hemangiomas occurred along the midline axis or perpendicularly across the ocular axis in a cross-shaped area of predilection intersecting at the glabella. Scalp hemangiomas show a predilection for the midline, with 149/295 (50.5%) note...Continue Reading

References

Jul 23, 2003·Archives of Dermatology·Milton WanerMartin C Mihm
Sep 18, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Mark E KleinmanGeoffrey C Gurtner
Apr 24, 2008·Pediatric Dermatology·Christine Kilcline, Ilona J Frieden
Jun 16, 2014·Journal of the American Academy of Dermatology·Nicole A WeitzAnita N Haggstrom
Sep 30, 2015·Pediatrics·Mark DiasUNKNOWN SECTION ON NEUROLOGIC SURGERY
Jul 12, 2016·Pediatric Dermatology·Daniel A YanesPatricia M Witman

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Citations

Aug 31, 2019·Pediatric Dermatology·Gemma Ochando-Ibernón, Jose Manuel Azaña-Defez
Mar 11, 2021·Journal of the American Academy of Dermatology·Yvonne E ChiuAmy S Paller
Sep 23, 2021·JAMA Dermatology·Alyson A EndicottAnita N Haggstrom
Aug 23, 2021·Journal of the American Academy of Dermatology·Ana I Rodríguez BanderaLi-Chuen F Wong

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