Localized intraarterial streptokinase therapy

American Journal of Surgery
J K Hamelink, B M Elliott

Abstract

In a retrospective study, 26 patients underwent 34 episodes of selective intraarterial streptokinase infusion for peripheral arterial thromboembolic occlusive disease. Thrombolytic therapy was beneficial in 23 instances (67 percent), caused no change in 7 instances, and caused deterioration in 4 instances. Nine patients (26 percent) had a major complication and 15 (44 percent) had a minor complication. Puncture site hematoma, which occurred in 11 cases (32 percent), was the most frequent complication. Local thrombolytic therapy is an effective primary or adjuvant method of treatment for thromboembolic occlusive disease in properly selected patients. Protocols for the safe use of streptokinase therapy are necessary. Enthusiasm for thrombolytic therapy must be tempered by the recognition of its potential for serious complications, the requirement for intensive care monitoring, and the availability of dedicated radiologists and vascular surgeons.

References

Dec 6, 1979·The New England Journal of Medicine·W R Bell, A G Meek
Apr 1, 1974·Radiology·C T DotterA J Seaman
Jan 1, 1984·Journal of Vascular Surgery·A van BredaC A Athanasoulis
Aug 1, 1983·Annals of Surgery·G A BerniD E Strandness
Sep 1, 1983·Radiology·G J BeckerE C Klatte
May 27, 1982·The New England Journal of Medicine·G V SharmaA A Sasahara

❮ Previous
Next ❯

Citations

Dec 1, 1988·American Journal of Surgery·C PriceT Tytle
Nov 1, 1987·American Journal of Surgery·J B Towne, D F Bandyk
Jan 1, 1994·Annals of Vascular Surgery·C K Shortell, K Ouriel
May 1, 1993·Annals of Vascular Surgery·G L Faggioli, J J Ricotta
Jan 1, 1991·Annals of Vascular Surgery·J L Mills, J M Porter
Jan 1, 1992·The British Journal of Surgery·D J BrowseR B Galland
Mar 1, 1991·The British Journal of Surgery·J J Earnshaw
Sep 1, 1993·The British Journal of Surgery·R B GallandG Hamilton
Mar 1, 1989·The British Journal of Surgery·K T MoranA V Persson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.